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Photochem Photobiol Sci ; 19(8): 1009-1021, 2020 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-32584352

RESUMEN

Ultraviolet light-emitting diodes (UV-LEDs) are a novel light source for phototherapy. This study aimed to evaluate the therapeutic effects of UV-LEDs on psoriasis. Importantly, 310 nm UV-LEDs have not been studied in psoriasis in vitro and in vivo. Effects due to 310 nm UV-LED and 311 nm narrowband ultraviolet B (NBUVB) irradiation were compared for suppressing IL-22-induced activation of STAT3 expression using cell viability assay, western blotting, and immunocytochemistry. C57BL/6 mice were topically treated with imiquimod (IMQ) for 6 consecutive days and degenerative changes were observed. Test groups were irradiated with a 310 nm UV-LED and 311 nm NBUVB. Phenotypic observations, histopathological examinations, and ELISA were conducted with skin and blood samples. STAT3-dependent IL-22 signalling and effects in keratinocytes are negatively regulated by the 310 nm UV-LED, which significantly ameliorated IMQ-induced psoriasis-like dermatitis development and reduced Th17 cytokine levels (IL-17A, IL-22) in serum and dorsal skin. Histopathological findings showed decreases in epidermal thickness and inflammatory T-cell infiltration in the UV-LED-irradiated groups. Quantitative PCR confirmed a UV radiation energy-dependent decrease in IL-17A and IL-22 mRNA levels. The results demonstrated that UV-LEDs had anti-inflammatory and immunoregulatory effects. So, UV-LED phototherapy inhibits psoriasis development by suppressing STAT3 protein and inflammatory cytokines and could be useful in treating psoriasis.


Asunto(s)
Inflamación/terapia , Interleucinas/metabolismo , Psoriasis/terapia , Factor de Transcripción STAT3/biosíntesis , Rayos Ultravioleta , Animales , Antineoplásicos/farmacología , Células HaCaT , Humanos , Imiquimod/farmacología , Inflamación/inducido químicamente , Inflamación/patología , Ratones , Ratones Endogámicos C57BL , Psoriasis/inducido químicamente , Psoriasis/patología , Piel/efectos de los fármacos , Piel/patología , Interleucina-22
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