RESUMEN
No abstract available.
Asunto(s)
Anciano , Humanos , Masculino , Terapia por Acupuntura , ADN/química , Ecocardiografía , Endocarditis/diagnóstico , Imagen por Resonancia Magnética , Reacción en Cadena de la Polimerasa , ARN Ribosómico 16S/genética , Análisis de Secuencia de ADN , Espondilitis/diagnóstico , Streptococcus/genéticaRESUMEN
Although extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) has emerged as a significant community-acquired pathogen, there is little epidemiological information regarding community-onset bacteremia due to ESBL-EC. A retrospective observational study from 2006 through 2011 was performed to evaluate the epidemiology of community-onset bacteremia caused by ESBL-EC. In a six-year period, the proportion of ESBL-EC responsible for causing community-onset bacteremia had increased significantly, from 3.6% in 2006 to 14.3%, in 2011. Of the 97 clinically evaluable cases with ESBL-EC bacteremia, 32 (33.0%) were further classified as healthcare-associated infections. The most common site of infection was urinary tract infection (n=35, 36.1%), followed by biliary tract infections (n=29, 29.9%). Of the 103 ESBL-EC isolates, 43 (41.7%) produced CTX-M-14 and 36 (35.0%) produced CTX-M-15. In the multilocus sequence typing (MLST) analysis of 76 isolates with CTX-M-14 or -15 type ESBLs, the most prevalent sequence type (ST) was ST131 (n=15, 19.7%), followed by ST405 (n=12, 15.8%) and ST648 (n=8, 10.5%). No significant differences in clinical features were found in the ST131 group versus the other group. These findings suggest that epidemic ESBL-EC clones such as CTX-M-14 or -15 type ESBLs and ST131 have disseminated in community-onset infections, even in bloodstream infections, which are the most serious type of infection.
Asunto(s)
Femenino , Humanos , Masculino , Envejecimiento , Bacteriemia/tratamiento farmacológico , Enfermedades de las Vías Biliares/epidemiología , Resistencia a las Cefalosporinas/genética , Cefalosporinas/uso terapéutico , Infecciones Comunitarias Adquiridas/epidemiología , Escherichia coli/aislamiento & purificación , Infecciones por Escherichia coli/tratamiento farmacológico , Pruebas de Sensibilidad Microbiana , Epidemiología Molecular , Tipificación de Secuencias Multilocus , Prevalencia , Estudios Retrospectivos , Infecciones Urinarias/epidemiología , beta-Lactamasas/metabolismoRESUMEN
No abstract available.