RESUMEN
Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction (MI), by far, there are few preventive and therapeutic options for ischemic heart failure (IHF) after MI. Qi-Tai-Suan (QTS) is an oleanolic acid (OA) derivative which once underwent a clinical trial for treating hepatitis. In this study, we investigated the potential cardioprotective effect of QTS on IHF. IHF mouse model was constructed by coronary artery ligation in male C57BL/6J mice, and the protective effects of QTS on IHF were examined by echocardiography measurement, histological and TUNEL analysis, etc. We found that QTS exhibited promising cardioprotective effect on IHF. QTS treatment significantly improved cardiac function of IHF mice and the symptoms of heart failure. Notably, QTS had much better oral bioavailability (F = 41.91%) in mice than its parent drug OA, and took effects mainly as its original form. Mechanistically, QTS ameliorated ischemic heart failure likely through suppression of cardiac apoptosis, inflammation and fibrosis. Taken together, QTS holds great promise as a preventive and therapeutic agent for ischemic heart failure and related diseases.
Asunto(s)
Animales , Masculino , Ratones , Apoptosis , Fibrosis , Insuficiencia Cardíaca/tratamiento farmacológico , Inflamación/tratamiento farmacológico , Ratones Endogámicos C57BL , Isquemia Miocárdica/patología , Ácido Oleanólico/farmacologíaRESUMEN
System combing the internal unity of traditional Chinese medicine culture and socialist core values is the demands of both contemporary TCM culture intrinsic appeal and also the practice of socialist core values. Based on exploring the inner link between the core value of traditional Chinese medicine culture and socialist core values, this article discuss the specific path of promoting socialist core values in the process of TCM culture inheritance and innovation.
RESUMEN
The pharmacokinetic research of traditional Chinese medicines (TMC) is an inalienable part of the chain of TCM modernization and plays an important role in the TCM novel drug development. However, the researching method and system that is consistent with the specific characteristics of TCM, i.e., multiple-components and targets, is still lacking. Furthermore, the current understanding of the critical scientific questions of TCM pharmacokinetics remains still unclear. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of TCMs, mainly including integral pharmacokinetic study of multiple components, herbalome analysis both in vitro and in vivo, mechanism based compatibility study for herbal components interactions, and the representative pharmacokinetic study for single herbal compound. Furthermore, the critical scientific questions of TCM pharmacokinetics are discussed based on understanding the requirements of novel drug developments from TCM.
Asunto(s)
Animales , Humanos , Combinación de Medicamentos , Interacciones Farmacológicas , Sinergismo Farmacológico , Medicamentos Herbarios Chinos , Farmacocinética , Medicina Tradicional China , Plantas Medicinales , Química , Análisis de Componente Principal , Relación Estructura-Actividad CuantitativaRESUMEN
Tussilago farfara contained the chemical constitutents including terpenes, flavonoids, and alkanoids. It has been used for the relief of coughs and as an expectorant, blood pressure raiser, platelet activating factor inhibitor and anti-inflammatory agents. This paper reviewed the phytochemical and pharmacological research progress in T. farfara, including the chemical ingredients, the pharmaceutical activities and the security evaluation aiming at its toxicity. The problems at present and the reseach direction for the future on T. farfara have been put forward.
Asunto(s)
Animales , Alcaloides , Química , Farmacología , Toxicidad , Evaluación Preclínica de Medicamentos , Métodos , Medicamentos Herbarios Chinos , Farmacología , Toxicidad , Flavonoides , Química , Farmacología , Toxicidad , Estructura Molecular , Plantas Medicinales , Química , Terpenos , Química , Farmacología , Toxicidad , Tussilago , QuímicaRESUMEN
<p><b>OBJECTIVE</b>To determine ginsenoside Rg1, Re, Rb1, Rc, Rb2, Rd from main root and root hair of red ginseng of different specifications.</p><p><b>METHOD</b>Ultrasonical extraction and reversed phase high performance liquid chromatography were applied.</p><p><b>RESULT</b>The total contents of six ginsenosides from main root 15 roots (percent 500 g), 20 roots, 30 roots and root hair are 1.21%, 1.46%, 1.54% and 8.16%, respectively.</p><p><b>CONCLUSION</b>The results showed that the bigger the volume of ginseng root, the less the content of ginsenoside.</p>