[Dilution of the toxic action of 5-fluorouracil on the mucosa of the small intestine in mice using the sap of plantain]. / Oslablenie toksicheskogo deistviia 5-ftoruratsila na slizistuiu obolochku tonkoi kishki myshei sokom podorozhnika.

The study was concerned with an attempt at reducing the acute toxic effect of 5-fluorouracil (5-FU) on gut mucosa in mice with Ehrlich ascites tumors. An official preparation of plantain sap was shown to ward off this effect and to contribute to the normalising of certain parameters of epithelial cells. The DNA level of tumor cells showed a more drastic decline after combined treatment with 5-FU and the preparation than after the cytostatic drug alone.

[Experimental data on the toxic action of hydrazine sulfate on the body and on a tumor]. / Eksperimenntal'nye dannye o tokisicheskom deistvii gidrazinsul'fata na organizm i opukhol'.

Toxic action of hydrozine sulfate in rats and mice along with its influence on the mitotic activity of Walker carcino-sarcoma cells were studied. Single injections of the agent in high doses resulted in destruction of the animals during the first 2 days with no "delayed death" observed. Multiple injections caused a considerable loss of body weight. When given in toxic doses the agent did not influence hemopoiesis, but did affect sensitivity, drastically increasing the toxic action of ethanol or barbiturates. Administration of hydrazine sulfate in therapeutic doses decreased markedly the mitotic activity and increased the appearance of atypical mitotic cells.