RESUMEN
3,5-Dihydroxy-6,7,8-trimethoxyflavone, 3-O-methylquercetin, and helichrysetin were isolated from the flowers of the Rwandese medicinal plant, Helichrysum odoratissimum. Because of inconsistencies of the mp of the latter chalcone, a synthesis of helichrysetin was developed. 3-O-Methylquercetin was shown to be an active principle as it displayed antimicrobial activity.
Asunto(s)
Antiinfecciosos/aislamiento & purificación , Chalcona/biosíntesis , Chalcona/aislamiento & purificación , Flavonoides/aislamiento & purificación , Plantas Medicinales/análisis , Propiofenonas/biosíntesis , Propiofenonas/aislamiento & purificación , Antiinfecciosos/síntesis química , Antiinfecciosos/farmacología , Chalcona/análogos & derivados , Chalcona/síntesis química , Pruebas de Sensibilidad MicrobianaRESUMEN
Tetradenia riparia is one of the most popular medicinal plants in Rwanda. Previously, several new substances have been isolated from the leaves of this plant, including a new diterpene diol, i.e. 8(14),15-sandaracopimaradiene-7 alpha,18-diol. This new diterpene diol exhibits significant antimicrobial activity against several bacteria and fungi. The minimum inhibitory concentration (MIC) of the substance for microorganisms which were inhibited ranged from 6.25 to 100 micrograms/ml.