RESUMEN
We studied the rates of the patient with the elevation of serum creatine kinase using the routine medical checkup data from KANEMI YUSHOU patients between 1995 and 2001. We also studied the serum aldolase level and light microscopic observation of muscle tissue in rats during strenuous exercise given the polychlolinated biphenyls. Fifteen percent of the patients showed the elevation of serum creatine kinase. The patients with the elevation of serum creatine kinase also showed a higher concentration of polychlolinated biphenyls in their blood. 47.7% of the patients show low aldolase. There is no interrelation between the aldolase levels and PCBs or PCQs. There is also no interrelation between the serum levels of aldolase and creatine kinase. The rats given polycholorinated biphenyls showed a slight increase of necrotic fibers during strenuous exercise. Polycholorinated biphenyls may play some role for muscle necrosis. We could not clarify the significance of low serum aldolase in KANEMI YUSHOU.