RESUMEN
Different antibiotics and chemotherapeutics were tested for therapeutic efficacy in rabbits, in an experimental model using a Pasteurella multocida strain which causes hyperacute septicaemia in this animal species. Only enrofloxacin, administered in the drinking water at a concentration of 50-100 mg/l cured the rabbits, provided that a daily intake of 5 mg/kg body weight was achieved. The other drugs tested (tetracycline, spiramycin, erythromycin and a combination of sulfamerazine with trimethoprim), at doses recommended for rabbits, showed little or no activity at all, with the exception of chloramphenicol, which was only partially effective.
Asunto(s)
Antibacterianos/uso terapéutico , Fluoroquinolonas , Infecciones por Pasteurella/veterinaria , Quinolonas , Conejos , Sepsis/veterinaria , 4-Quinolonas , Administración Oral , Animales , Antibacterianos/administración & dosificación , Antiinfecciosos/administración & dosificación , Antiinfecciosos/uso terapéutico , Cloranfenicol/uso terapéutico , Evaluación Preclínica de Medicamentos , Enrofloxacina , Infecciones por Pasteurella/tratamiento farmacológico , Sepsis/tratamiento farmacológicoRESUMEN
Mice were immunized with different preparations of a killed whole cell Pasteurella multocida vaccine and challenged with successive tenfold dilutions of the homologous strain. Vaccines adjuvanted with mineral oil did not confer better protection against death than non-adjuvanted suspensions, even when the mice were challenged at 3 months after vaccination. Very good protection was obtained when the non-adjuvanted suspension had been administered twice.
Asunto(s)
Adyuvantes Inmunológicos , Vacunas Bacterianas/inmunología , Infecciones por Pasteurella/prevención & control , Pasteurella/inmunología , Animales , Emulsiones , Inmunización , Ratones , Aceites , Conejos/inmunología , Vacunas Atenuadas/inmunologíaRESUMEN
Different inactivated P. multocida vaccines were investigated for their protective capacities against experimental infection with virulent P. multocida strains in SPF rabbits. It was found that bacterins without adjuvant and bacterins combined with the adjuvants tested provoked immunity against aerosol infection with homologous strains. However, most bacterins tested caused local tissue irritation. Further work was done with oil adjuvant vaccines because lesions were less severe with this type of vaccine. Some of the multicomponent vaccines tested gave good immunity against heterologous infection, while others did not.