The use of phototherapy in peripheral nerve regeneration: an updated critical review.

This review describes the possible factors that may have contributed to the variability of the results between studies that have assessed the effects of phototherapy on peripheral nerve regeneration. Furthermore, it aims to make recommendations to overcome the methodological shortcomings identified. A search of the literature was conducted. In vitro and in vivo experimental studies and clinical trials were included. Twenty five studies were critically reviewed and showed considerable variability in irradiation parameters, techniques, approaches, length of irradiation courses, experimental injury tools and procedures. Many studies that have investigated the use of phototherapy in nerve regeneration produce positive results. However, the majority of these studies suffered from a number of shortcomings: no evidence of blinding and/or randomizing procedures, lack of specification of irradiation parameters, unspecified and/or inadequate tests in their experimental injury procedures, inappropriate irradiation parameters and/or poor experimental conditions.

Electric muscle stimulation of the quadriceps in the treatment of patellofemoral pain.

OBJECTIVE: To compare a commercially available electric muscle stimulation regimen with a novel form of stimulation for the rehabilitation of the quadriceps muscle, in patients with patellofemoral pain syndrome. DESIGN: Double-blinded randomized trial with a parallel control group and stratified randomization. SETTING: Home-based rehabilitation program assessed in research center. PARTICIPANTS: Eighty patients (47 women, 33 men) with patellofemoral pain syndrome. INTERVENTIONS: One group (EMPI) received 1 uniform constant frequency component of 35Hz. The other (EXPER) group received an experimental form of stimulation that contained 5 simultaneously delivered frequency components of 125, 83, 50, 2.5, and 2Hz. Stimulation was applied to the quadriceps muscles of the affected leg for 1 hour daily for 6 weeks, a total of 42 treatments. MAIN OUTCOME MEASURES: Lower-limb isometric and isokinetic torque, quadriceps fatigue, knee flexion, patellar pain, a step test, quadriceps cross-sectional area, and Kujala patellofemoral score for pain before and after treatment. RESULTS: Seventy-four patients (43 women, 31 men) completed the trial. Patients in both groups showed significant improvements in all outcomes (P<.05). No significant differences existed between the 2 stimulators in any outcome (P>.05) except for quadriceps cross-sectional area (P=.023). CONCLUSIONS: One form of stimulation was just as efficacious as the other in improving subjective and objective measures.

Neuromuscular stimulation of the quadriceps muscle after hip fracture: a randomized controlled trial.

OBJECTIVE: To study the feasibility and effect of neuromuscular stimulation on recovery of mobility after surgical fixation for hip fracture. DESIGN: Double-blind study with stratified randomization. SETTING: Home-based rehabilitation program. PARTICIPANTS: Twenty-four women over the age of 75 years with hip fracture. INTERVENTIONS: Neuromuscular or placebo stimulation of the quadriceps muscle of the fractured leg, applied for 3 hours a day, for 6 weeks, commencing 1 week after surgery. MAIN OUTCOME MEASURES: Recovery of walking speed and ability, postural stability, lower-limb muscle power, and pain at 7 and 13 weeks after surgery. RESULTS: Women in the neuromuscular stimulation group showed faster recovery of mobility. Of the women receiving stimulation, 9 of 12 recovered their prior levels of indoor mobility ability by 13 weeks compared with 3 of 12 in the placebo group (Fisher exact test, P=.046). There were no differences in recovery of walking speed in the first 7 weeks, but women in the stimulation group had greater recovery between 7 and 13 weeks (mean difference=-.13m/s; 95% confidence interval, -.23 to -.01). CONCLUSIONS: Neuromuscular stimulation at home is feasible and may be effective in speeding recovery of mobility after surgical fixation of hip fracture.