RESUMEN
At urography the radiopacity of the pelvis increases with the product of iodine concentration of the urine and its layer thickness. The layer thickness is proportional to the third root of the volume. Using this knowledge, we estimated the volume of the renal pelvis in rabbits and found it to be proportional to the diuresis up to a level of approximately 0.8 ml per min, after which a maximal dilatation seemed to be reached. By this means, the estimated density of the renal pelvis can be calculated. This model of evaluating urographic contrast agents is thought to be more appropriate than and complementary to the mere determination of urinary iodine concentration.
Asunto(s)
Pelvis Renal/diagnóstico por imagen , Enfermedades Ureterales/diagnóstico por imagen , Urografía , Animales , Medios de Contraste , Radioisótopos de Yodo , Conejos , Cintigrafía , Orina/análisisRESUMEN
The relation between ionic composition and cardiotoxicity of two dimers, iocarmate and iozomate, was investigated by selective injection into the left and right coronary arteries, Least toxic reactions developed at a sodium concentration of 263 to 315 mmol/l for sodium-meglumine iocarmate and 271 to 379 mmol/l for sodium-meglumine iozomate.
Asunto(s)
Arritmias Cardíacas/inducido químicamente , Angiografía Coronaria , Diatrizoato/análogos & derivados , Sistema de Conducción Cardíaco/efectos de los fármacos , Yotalamato de Meglumina/toxicidad , Ácido Yotalámico/análogos & derivados , Animales , Complejos Cardíacos Prematuros/inducido químicamente , Diatrizoato/administración & dosificación , Diatrizoato/toxicidad , Evaluación Preclínica de Medicamentos , Bloqueo Cardíaco/inducido químicamente , Inyecciones Intraarteriales , Yotalamato de Meglumina/administración & dosificación , Concentración Osmolar , Conejos , Fibrilación Ventricular/inducido químicamenteRESUMEN
Two different iodized oil emulsion have been intravascularly injected into rabbits, one with a particle size of 15 mum or more and one with a size of about 1 mum. The effects of the emulsions have been evaluated on the brain, the heart, the kidney, the liver and the circulation. The reactions to the small particle emulsion was minor, especially if administered slowly. The injection site was of critical importance. The safest place for injection was the superior mesenteric artery. If supplied directly to the brain or the heart the emulsions were often deleterious, particularly the coarse one.