RESUMEN
Three new cyclized geranyl stilbenes, ugonstilbene A ( 1), ugonstilbene B ( 2), and ugonstilbene C ( 3), and one known compound 3-hydroxyacetophenone, were isolated from the dried rhizomes of H. zeylanica. The structures of these three new compounds were elucidated on the basis of spectral analysis. Compounds 1 - 3 exhibited moderate antioxidant activity by the DPPH assay with IC (20) of 11.31 +/- 1.11, 38.72 +/- 0.47, and 30.80 +/- 1.19 microM, respectively, while the IC (20) of Trolox was 8.70 +/- 0.95 microM.
Asunto(s)
Antioxidantes/farmacología , Helechos , Fitoterapia , Extractos Vegetales/farmacología , Antioxidantes/química , Compuestos de Bifenilo , Humanos , Espectroscopía de Resonancia Magnética , Picratos , Extractos Vegetales/química , Rizoma , Estilbenos/química , Estilbenos/farmacologíaRESUMEN
Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).
Asunto(s)
4-Butirolactona/farmacología , Anisoles/farmacología , Dioxoles/farmacología , Virus de la Hepatitis B/efectos de los fármacos , Taninos Hidrolizables , Lignanos , Phyllanthus , Extractos Vegetales/farmacología , 4-Butirolactona/análogos & derivados , 4-Butirolactona/aislamiento & purificación , Anisoles/aislamiento & purificación , Benzodioxoles , Técnicas de Cultivo , Dioxoles/aislamiento & purificación , Ensayo de Inmunoadsorción Enzimática , Glucósidos/aislamiento & purificación , Glucósidos/farmacología , Antígenos de Superficie de la Hepatitis B/biosíntesis , Antígenos de Superficie de la Hepatitis B/efectos de los fármacos , Antígenos e de la Hepatitis B/biosíntesis , Antígenos e de la Hepatitis B/efectos de los fármacos , Virus de la Hepatitis B/crecimiento & desarrollo , Virus de la Hepatitis B/metabolismo , Humanos , Estructura Molecular , Fitoterapia , Extractos Vegetales/química , Taninos/aislamiento & purificación , Taninos/farmacologíaRESUMEN
Five new homoisoflavonoids, ophiopogonanone C (1), ophiopogonanone D (2), ophiopogonone C (3), ophiopogonanone E (4) and ophiopogonanone F (5), and six known compounds were isolated from an ethanol extract of the tubers of Ophiopogon japonicus (Thunb) Ker-Gawl. Spectroscopic analyses were used to elucidate the structures of these compounds.