RESUMEN
In April 1997, a severe lead poisoning in humans was reported in rural Albania and a 30-y-old male and a 17-y-old female died. Twenty-three persons exhibiting signs of lead intoxication recovered following intensive EDTA-Ca chelation therapy. The poisoning resulted from lead contaminated flour originating from repair of a mill's cracked grindstone with metallic lead. Lead levels in flour samples averaged 325 +/- 18 ppm and in bran were 370 +/- 22 ppm. Blood lead levels in intoxicated individuals averaged 0.42 +/- 0.05 ppm and were compatible with their symptomatic status. Contaminated bran from the same mill was fed to lactating cows as well. Lead levels in blood and milk of exposed cows averaged 0.27 +/- 0.06 and 0.61 +/- 0.04 ppm, respectively.
Asunto(s)
Quelantes/uso terapéutico , Ácido Edético/uso terapéutico , Contaminación de Alimentos , Intoxicación por Plomo/tratamiento farmacológico , Adolescente , Adulto , Albania , Animales , Bovinos , Enfermedades de los Bovinos/tratamiento farmacológico , Femenino , Harina/análisis , Humanos , Plomo/análisis , Plomo/sangre , Intoxicación por Plomo/sangre , Intoxicación por Plomo/veterinaria , Masculino , Leche/químicaRESUMEN
In early February 1996 severe lead intoxication in humans was reported from a rural area of Albania. An entire family of 5 individuals was involved and 2 of them died. The origin of the poisoning was lead-contaminated flour used by the family on a regular basis in their diet. The flour lead levels ranged between 550 to 800 ppm. Following 2 days of treatment with EDTA-Ca the blood lead concentration in survivors varied between 16 and 58 micrograms/dL blood.
Asunto(s)
Antídotos/uso terapéutico , Ácido Edético/uso terapéutico , Contaminación de Alimentos , Intoxicación por Plomo , Albania , Antídotos/administración & dosificación , Niño , Preescolar , Ácido Edético/administración & dosificación , Femenino , Análisis de los Alimentos , Humanos , Lactante , Plomo/sangre , Intoxicación por Plomo/tratamiento farmacológico , Intoxicación por Plomo/mortalidad , Masculino , Valores de Referencia , Espectrofotometría AtómicaAsunto(s)
Colchicina/toxicidad , Colchicum , Intoxicación por Plantas/veterinaria , Plantas Medicinales , Enfermedades de las Ovejas/etiología , Albania , Animales , Médula Ósea/efectos de los fármacos , Médula Ósea/metabolismo , Cromatografía en Capa Delgada , Colchicina/análisis , Colchicina/metabolismo , Colchicum/química , Femenino , Corazón/efectos de los fármacos , Riñón/efectos de los fármacos , Riñón/metabolismo , Lactancia/efectos de los fármacos , Hígado/efectos de los fármacos , Hígado/metabolismo , Pulmón/efectos de los fármacos , Pulmón/metabolismo , Leche/química , Músculos/efectos de los fármacos , Músculos/metabolismo , Miocardio/metabolismo , Extractos Vegetales/análisis , Extractos Vegetales/metabolismo , Extractos Vegetales/toxicidad , Intoxicación por Plantas/etiología , Estándares de Referencia , Ovinos , Bazo/efectos de los fármacos , Bazo/metabolismo , Distribución TisularRESUMEN
The present communication describes the use of a quantitative thin-layer-chromatography method for the determination of colchicine in milk of a lactating sheep following a 10 mg single oral intake of the alkaloid extracted from the leaves of Colchicum autumnale. The concentration of the alkaloid in the leaves was 0,18% by weight. Unchanged colchicine can be detected in milk with the described method within the first 6 hours following the intake, whereas the maximal concentration of the alkaloid is reached 9 hours after the administration. Almost 40 hours following the intake the detection of the alkaloid in milk is not more possible. Postmortal determinations of the tissue levels of the alkaloid revealed major concentrations in the bone marrow, whereas only trace amounts were identified in heart and muscular tissue.