RESUMEN
In continuation of our work on Indian celery (Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOH-H(2) O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cytotoxicity to some yeast strains. Compound 1 also showed spasmolytic activity. On the other hand, isopimpinellin (3) and isorutarin (5) exhibited a spasmogenic effect on the smooth muscle preparations. Compound 5 was also found to have antioxidant activity. Among them, compound 4 was isolated for the first time from this plant.
Asunto(s)
Antioxidantes/farmacología , Apiaceae/química , Diuréticos/farmacología , Parasimpatolíticos/farmacología , Extractos Vegetales/farmacología , Semillas/química , Antioxidantes/química , Antioxidantes/aislamiento & purificación , Benzodioxoles/química , Benzodioxoles/aislamiento & purificación , Benzodioxoles/farmacología , Supervivencia Celular/efectos de los fármacos , Cumarinas/química , Cumarinas/aislamiento & purificación , Cumarinas/farmacología , Diuréticos/química , Diuréticos/aislamiento & purificación , Furocumarinas/química , Furocumarinas/aislamiento & purificación , Furocumarinas/farmacología , Contracción Muscular/efectos de los fármacos , Músculo Liso/efectos de los fármacos , Músculo Liso/fisiología , Parasimpatolíticos/química , Parasimpatolíticos/aislamiento & purificación , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificaciónRESUMEN
A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.
Asunto(s)
Isodon/química , Triterpenos/aislamiento & purificación , Cristalografía por Rayos X , Saccharomyces cerevisiae/efectos de los fármacos , Triterpenos/químicaRESUMEN
Two new diterpene lactones, suregadolides A (1) and B (2), were isolated from a dichloromethane extract of Suregada multiflora bark. These compounds possess a novel skeleton, which contains a cyclopropane ring bridging C-3 and C-4 of the abietane skeleton. The structures were established on the basis of one- and two-dimensional NMR and other spectroscopic studies. Compound 1 showed moderate inhibitory activity in a mutant yeast strain bioassay.