Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros

Bases de datos
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
Nat Commun ; 12(1): 5958, 2021 10 13.
Artículo en Inglés | MEDLINE | ID: mdl-34645820

RESUMEN

Understanding the functional potential of the gut microbiome is of primary importance for the design of innovative strategies for allergy treatment and prevention. Here we report the gut microbiome features of 90 children affected by food (FA) or respiratory (RA) allergies and 30 age-matched, healthy controls (CT). We identify specific microbial signatures in the gut microbiome of allergic children, such as higher abundance of Ruminococcus gnavus and Faecalibacterium prausnitzii, and a depletion of Bifidobacterium longum, Bacteroides dorei, B. vulgatus and fiber-degrading taxa. The metagenome of allergic children shows a pro-inflammatory potential, with an enrichment of genes involved in the production of bacterial lipo-polysaccharides and urease. We demonstrate that specific gut microbiome signatures at baseline can be predictable of immune tolerance acquisition. Finally, a strain-level selection occurring in the gut microbiome of allergic subjects is identified. R. gnavus strains enriched in FA and RA showed lower ability to degrade fiber, and genes involved in the production of a pro-inflammatory polysaccharide. We demonstrate that a gut microbiome dysbiosis occurs in allergic children, with R. gnavus emerging as a main player in pediatric allergy. These findings may open new strategies in the development of innovative preventive and therapeutic approaches. Trial: NCT04750980.


Asunto(s)
Alérgenos/inmunología , Hipersensibilidad a los Alimentos/microbiología , Microbioma Gastrointestinal/inmunología , Tolerancia Inmunológica , Hipersensibilidad Respiratoria/microbiología , Alérgenos/efectos adversos , Animales , Bacteroides/aislamiento & purificación , Bacteroides/metabolismo , Bifidobacterium longum/aislamiento & purificación , Bifidobacterium longum/metabolismo , Estudios de Casos y Controles , Niño , Preescolar , Clostridiales/aislamiento & purificación , Clostridiales/metabolismo , Alérgenos Animales/efectos adversos , Alérgenos Animales/inmunología , Huevos/efectos adversos , Faecalibacterium prausnitzii/aislamiento & purificación , Faecalibacterium prausnitzii/metabolismo , Femenino , Hipersensibilidad a los Alimentos/etiología , Hipersensibilidad a los Alimentos/inmunología , Humanos , Lipopolisacáridos/biosíntesis , Masculino , Leche/efectos adversos , Leche/inmunología , Nueces/efectos adversos , Nueces/inmunología , Polen/química , Polen/inmunología , Prunus persica/química , Prunus persica/inmunología , Pyroglyphidae/química , Pyroglyphidae/inmunología , Hipersensibilidad Respiratoria/etiología , Hipersensibilidad Respiratoria/inmunología , Ureasa/biosíntesis
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA