Anti-oxidant potential of plants and probiotic spp. in alleviating oxidative stress induced by H2O2.

Cells produce reactive oxygen species (ROS) as a metabolic by-product. ROS molecules trigger oxidative stress as a feedback response that significantly initiates biological processes such as autophagy, apoptosis, and necrosis. Furthermore, extensive research has revealed that hydrogen peroxide (H2O2) is an important ROS entity and plays a crucial role in several physiological processes, including cell differentiation, cell signalling, and apoptosis. However, excessive production of H2O2 has been shown to disrupt biomolecules and cell organelles, leading to an inflammatory response and contributing to the development of health complications such as collagen deposition, aging, liver fibrosis, sepsis, ulcerative colitis, etc. Extracts of different plant species, phytochemicals, and Lactobacillus sp (probiotic) have been reported for their anti-oxidant potential. In this view, the researchers have gained significant interest in exploring the potential plants spp., their phytochemicals, and the potential of Lactobacillus sp. strains that exhibit anti-oxidant properties and health benefits. Thus, the current review focuses on comprehending the information related to the formation of H2O2, the factors influencing it, and their pathophysiology imposed on human health. Moreover, this review also discussed the anti-oxidant potential and role of different extract of plants, Lactobacillus sp. and their fermented products in curbing H2O2­induced oxidative stress in both in-vitro and in-vivo models via boosting the anti-oxidative activity, inhibiting of important enzyme release and downregulation of cytochrome c, cleaved caspases-3, - 8, and - 9 expression. In particular, this knowledge will assist R&D sections in biopharmaceutical and food industries in developing herbal medicine and probiotics-based or derived food products that can effectively alleviate oxidative stress issues induced by H2O2 generation.

Synthesis, characterization, and utilization of potato starch nanoparticles as a filler in nanocomposite films.

The nanoparticles for the preparation of nanocomposite starch films were synthesized from potato starch using the acid hydrolysis method. The films were prepared by incorporating starch nanoparticles into the film formulation at 0.5, 1, 2, 5, and 10% level of total starch. The control starch film was prepared without the incorporation of starch nanoparticles (SNPs) in film formulation. The starch and SNPs were analyzed for physicochemical and morphological properties. The absorption capacity of SNPs for water and oil was significantly (p < 0.05) lower as compared to native starch. Whereas, the swelling power and solubility of SNPs were significantly (p < 0.05) higher than the swelling power and solubility of starch, respectively. The starch granules were oval and spherical with regular surfaces whereas the SNPs had irregular cracked exteriors spaces. The water vapor transmission rate (WVTR) from nanocomposite starch films was significantly (p < 0.05) lower than the control starch film. The burst strength of films was increased significantly (p < 0.05) with an increased level of SNPs incorporation in film formulation. The incorporation of SNPs increased film thickness and biodegradability. Thus, the present study revealed that the incorporation of SNPs in film formulation resulted in improved film properties.