RESUMEN
OBJECTIVE: To trace and document smaller changes in perinatal survival over time. DESIGN: Prospective observational study, with retrospective analysis. SETTING: Labor ward and operating theater at Haydom Lutheran Hospital in rural north-central Tanzania. PARTICIPANTS: All women giving birth and birth attendants. INTERVENTION: Helping Babies Breathe (HBB) simulation training on newborn care and resuscitation and some other efforts to improve perinatal outcome. MAIN OUTCOME MEASURE: Perinatal survival, including fresh stillbirths and early (24-h) newborn survival. RESULT: The variable life-adjusted plot and cumulative sum chart revealed a steady improvement in survival over time, after the baseline period. There were some variations throughout the study period, and some of these could be linked to different interventions and events. CONCLUSION: To our knowledge, this is the first time statistical process control methods have been used to document changes in perinatal mortality over time in a rural Sub-Saharan hospital, showing a steady increase in survival. These methods can be utilized to continuously monitor and describe changes in patient outcomes.
Asunto(s)
Asfixia Neonatal/terapia , Partería/educación , Mortalidad Perinatal/tendencias , Resucitación/educación , Adulto , Femenino , Humanos , Lactante , Recién Nacido , Embarazo , Estudios Prospectivos , Estudios Retrospectivos , Mortinato , Tanzanía , Centros de Atención TerciariaRESUMEN
Globally, the burden of deaths and illness is still unacceptably high at the day of birth. Annually, approximately 300.000 women die related to childbirth, 2.7 million babies die within their first month of life, and 2.6 million babies are stillborn. Many of these fatalities could be avoided by basic, but prompt care, if birth attendants around the world had the necessary skills and competencies to manage life-threatening complications around the time of birth. Thus, the innovative Helping Babies Survive (HBS) and Helping Mothers Survive (HMS) programs emerged to meet the need for more practical, low-cost, and low-tech simulation-based training. This paper provides users of HBS and HMS programs a 10-point list of key implementation steps to create sustained impact, leading to increased survival of mothers and babies. The list evolved through an Utstein consensus process, involving a broad spectrum of international experts within the field, and can be used as a means to guide processes in low-resourced countries. Successful implementation of HBS and HMS training programs require country-led commitment, readiness, and follow-up to create local accountability and ownership. Each country has to identify its own gaps and define realistic service delivery standards and patient outcome goals depending on available financial resources for dissemination and sustainment.
Asunto(s)
Parto Obstétrico/educación , Mortalidad Infantil , Partería/educación , Mortinato/epidemiología , Parto Obstétrico/mortalidad , Países en Desarrollo , Femenino , Humanos , Lactante , Recién Nacido , Madres , Parto , EmbarazoAsunto(s)
Reanimación Cardiopulmonar/normas , Servicios Médicos de Urgencia/normas , Paro Cardíaco/terapia , Manejo de la Vía Aérea/métodos , Manejo de la Vía Aérea/normas , Daño Encefálico Crónico/epidemiología , Daño Encefálico Crónico/etiología , Daño Encefálico Crónico/prevención & control , Reanimación Cardiopulmonar/educación , Reanimación Cardiopulmonar/métodos , Salas de Parto/normas , Parto Obstétrico/métodos , Urgencias Médicas , Servicios Médicos de Urgencia/métodos , Medicina Basada en la Evidencia , Femenino , Paro Cardíaco/tratamiento farmacológico , Masaje Cardíaco/efectos adversos , Masaje Cardíaco/métodos , Masaje Cardíaco/normas , Humanos , Incubadoras para Lactantes , Cuidado del Lactante/métodos , Cuidado del Lactante/normas , Recién Nacido , Recien Nacido Prematuro , Enfermedades del Prematuro/fisiopatología , Enfermedades del Prematuro/terapia , Monitoreo Fisiológico/métodos , Monitoreo Fisiológico/normas , Estudios Observacionales como Asunto , Embarazo , Complicaciones del Embarazo , Respiración Artificial/métodos , Respiración Artificial/normas , Tasa de SupervivenciaRESUMEN
BACKGROUND: Early neonatal mortality has remained high and unchanged for many years in Tanzania, a resource-limited country. Helping Babies Breathe (HBB), a novel educational program using basic interventions to enhance delivery room stabilization/resuscitation, has been developed to reduce the number of these deaths. METHODS: Master trainers from the 3 major referral hospitals, 4 associated regional hospitals, and 1 district hospital were trained in the HBB program to serve as trainers for national dissemination. A before (n = 8124) and after (n = 78 500) design was used for implementation. The primary outcomes were a reduction in early neonatal deaths within 24 hours and rates of fresh stillbirths (FSB). RESULTS: Implementation was associated with a significant reduction in neonatal deaths (relative risk [RR] with training 0.53; 95% confidence interval [CI] 0.43-0.65; P ≤ .0001) and rates of FSB (RR with training 0.76; 95% CI 0.64-0.90; P = .001). The use of stimulation increased from 47% to 88% (RR 1.87; 95% CI 1.82-1.90; P ≤ .0001) and suctioning from 15% to 22% (RR 1.40; 95% CI 1.33-1.46; P ≤ .0001) whereas face mask ventilation decreased from 8.2% to 5.2% (RR 0.65; 95% CI 0.60-0.72; P ≤ .0001). CONCLUSIONS: HBB implementation was associated with a significant reduction in both early neonatal deaths within 24 hours and rates of FSB. HBB uses a basic intervention approach readily applicable at all deliveries. These findings should serve as a call to action for other resource-limited countries striving to meet Millennium Development Goal 4.
Asunto(s)
Asfixia Neonatal/mortalidad , Asfixia Neonatal/enfermería , Países en Desarrollo , Capacitación en Servicio/organización & administración , Partería/educación , Ventilación no Invasiva , Resucitación/educación , Resucitación/enfermería , Mortinato/epidemiología , Enseñanza/organización & administración , Puntaje de Apgar , Causas de Muerte , Competencia Clínica , Curriculum , Femenino , Humanos , Recién Nacido , Enfermedades del Prematuro/mortalidad , Enfermedades del Prematuro/enfermería , Masculino , Evaluación de Programas y Proyectos de Salud , Análisis de Supervivencia , Tasa de Supervivencia , TanzaníaRESUMEN
Nutrients exert unique regulatory effects in the perinatal period that mold the developing immune system. The interactions of micronutrients and microbial and environmental antigens condition the post-birth maturation of the immune system, influencing reactions to allergens, fostering tolerance towards the emerging gastrointestinal flora and ingested antigens, and defining patterns of host defense against potential pathogens. The shared molecular structures that are present on microbes or certain plants, but not expressed by human cells, are recognized by neonatal innate immune receptors. Exposure to these activators in the environment through dietary intake in early life can modify the immune response to allergens and prime the adaptive immune response towards pathogens that express the corresponding molecular structures.
Asunto(s)
Tracto Gastrointestinal/microbiología , Fenómenos Fisiológicos Nutricionales del Lactante/inmunología , Micronutrientes/inmunología , Fenómenos Fisiologicos de la Nutrición Prenatal/inmunología , Femenino , Tracto Gastrointestinal/crecimiento & desarrollo , Tracto Gastrointestinal/inmunología , Humanos , Inmunidad Innata , Recién Nacido , Masculino , Desnutrición/inmunología , Desnutrición/fisiopatología , EmbarazoRESUMEN
The mechanism of neuroprotection associated with systemically administered magnesium remains unclear. This investigation examined the acute effects of systemically administered MgSO4 on brain extracellular ([Mg]ecf) and intracellular ([Mg]i) fluid Mg concentrations, specific brain phosphorylated metabolites, and brain intracellular pH. Miniswine were studied with P-31 magnetic resonance spectra, to derive [Mg]i, and brain microdialysis probes, to measure [Mg]ecf. Animals were infused with MgSO4 (n = 5, 275 mg/kg over 30 min followed by 100 mg/kg over 30 min, designated MgHI) or Na2SO4 (n = 5, designated NaHI), and both groups underwent hypoxia-ischemia (HI) over the last 15 min of the infusions. Groups differed in plasma [Mg] at the completion of HI (9.1 +/- 1.5 versus 1.1 +/- 0.6 mM for MgHI and NaHI, respectively, p < 0.05). MgHI had elevations of [Mg]ecf (0.23 +/- 0.11 and 0.40 +/- 0.14 mM at control and completion of HI, respectively), and [Mg]ecf was unchanged for NaHI (p < 0.05 versus MgHI). At the completion of HI, MgHI had greater decreases in nucleoside triphosphate (NTP) (48 +/- 6% of control), and more brain acidosis after HI (6.01 +/- 0.07) compared with NaHI (NTP, 70 +/- 3% of control; brain pH, 6.51 +/- 0.14, both p < 0.05 versus MgHI). [Mg]i increased to elevated values during HI in both MgHI and NaHI (p < 0.05 versus control of each group) and remained higher in MgHI over the next 25 min (p < 0.05 versus NaHI). There were inverse correlations during HI between [Mg]i and brain NTP (r2 = 0.73 and 0.59 for MgHI and NaHI, respectively), and brain acidosis (r2 = 0.85 and 0.85 for MgHI and NaHI, respectively) in each group. These findings indicate complex effects of Mg on the brain. Elevation of [Mg]ecf may be beneficial with regards to excitatory neurotransmitters. However, greater disturbance of brain NTP concentration, more acidosis, and the increase in [Mg]i may offset any benefit. The results warrant further investigation using indicators of neuronal injury to determine whether Mg supplementation provides neuroprotection.