1.
Bioorg Med Chem Lett
; 19(15): 4250-4, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19505826
RESUMEN
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4'-azidocytidine (R1479), with variation on the ester, amino acid and aryl moiety of the ProTide. Sub-muM inhibitors of HCV emerge. The compounds are all non-cytotoxic in the replicon assay. We herein report detailed SARs for each of the regions of the ProTide.