[Sanatorium-and-spa treatment of patients who have had a new coronavirus infection (COVID-19)]. / Sanatorno-kurortnoe lechenie patsientov, perenesshikh novuyu koronavirusnuyu infektsiyu (COVID-19).

PURPOSE OF THE STUDY: Evaluation of the effectiveness of sanatorium-and-spa treatment of patients who have undergone a new coronavirus infection (COVID-19), taking into account the polymorphism of symptom complexes. MATERIAL AND METHODS: The study included 56 patients (22 men, 34 women; mean age 64.9±8.21 and 64.76±9.12 years, respectively) who had COVID-19 and were treated at a spa. The mandatory program of rehabilitation and rehabilitation sanatorium treatment included: exercise therapy with elements of breathing exercises, general massage with an emphasis on the chest, halo and speleotherapy, hydrotherapy, inhalations, as well as psychotherapeutic methods. The length of stay in the sanatorium was at least 2 weeks. We assessed the dynamics of indicators characterizing the activity of the cardiovascular and respiratory systems (BP, heart rate, Stange test), exercise tolerance (6-minute walk test), as well as psycho-emotional state (test «Health, Activity, Mood¼, SAN) up to and after treatment. RESULTS: Against the background of sanatorium-and-spa treatment in patients who underwent COVID-19, the number of complaints significantly decreased: in men from 6.2±2.4 to 3.4±1.3, in women from 7.7±1.5 to 4.12±1.5 (p≤0.05). A similar dynamics of indicators characterizing the activity of the cardiovascular system was noted: the level of systolic blood pressure in men decreased by 7.3%, in women - by 10.3%; the level of diastolic blood pressure - by 4.1 and 1.4%, respectively. Heart rate in men decreased from 83.69±15.2 to 75.54±12.24 beats/min; in women - from 92.16±14.16 to 76.4±11.68 beats/min. The distance traveled for men (6-minute walk test) increased from 384.15±108.78 to 408.92±97.30 m; in women - from 371.84±75.9 to 397.12±76.2 m (p≤0.05). The breath holding time on inspiration (Stange test) in men increased from 38.00±10.64 to 45.69±9.51 s; in women - from 39.96±9.31 to 43.60±6.93 s. The values of the «Well-being¼ indicator (SAN test) in men significantly increased - from 4.5±1.8 to 5.1±0.9 points (p≤0.05); «Activity¼ - from 4.8±0.8 to 5.4±0.5 points (p≤0.05); «Mood¼ - from 4.7±1.4 to 5.4±0.6 points. Similar dynamics were observed in women. CONCLUSION: Against the background of the sanatorium stage of treatment, a stable positive dynamics of the indicators of the functional state of the body was noted in both men and women. The analysis carried out confirms the need to develop and implement rehabilitation programs in sanatorium-resort conditions for patients who have had a new coronavirus infection.

[Combined treatment of palmoplantar syndrome in patients under antitumor therapy].

Observation covered 12 patients under various antitumor medications. Group 1 was formed of patients with developed palmoplantar syndrome varying in severity, who received complex treatment including IR-therapy and local antioxidant medication. Group 2 included patients without palmoplantar syndrome, who received preventive treatment with IR-therapy. All patients of group 1 demonstrated lower severity of palmoplantar syndrome manifestations. In group 2, 80% of the patients avoided palmoplantar syndrome development, and 20% of the patients had light course of the syndrome manifestations. Patients at high risk of palmoplantar syndrome under antitumor therapy are recommended to undergo IR-therapy and local antioxidant medication.

[Principles of constructing synbiotic preparations, and evaluation of their clinical effectiveness].

The problem of constructing means of correction of gastrointestinal microflora is utterly important. The most promising direction here seems to be construction of synbiotics containing a multiprobiotic complex of bifidobacteria and lactobacilli, modeling the microbiocenosis of a certain age group, inulin, as a prebiotic factor and a vitamin and mineral complex. The aim of the study was to evaluate the biologically active food supplement "Normospectrum" vs. the commercial preparation "Bifidumbacterin", its ability to correct the intestinal microflora and the functional condition of the gastrointestinal tract in children. "Normospectrum" was well tolerated, favored regression of the main clinical manifestations, and had positive effect on the intestinal microbiocenosis, increasing the proportion of bifidobacteria, lactobacilli and escherichiae with full enzymatic activity, and lowering the proportion of conditionally pathogenic bacteria and fungi in the intestinal tract. The effects of "Normospectrum" on the functional disturbances of the gastrointestinal tract and the intestinal microflora were much more profound than those of "Bifidumbacterin". Good tolerance and positive effects of the new probiotic preparation "Normospectrum" on the intestinal microbiosis allows recommending it for broad clinical application in children when correction of dysbiotic shifts in the intestinal microflora is necessary.

[Effect of peloid therapy on morphofunctional changes of ovaries and oviducts caused by suturing (experimental study)]. / Vliianie peloidoterapii na morfofunktsional'nye izmeneniia iaichnikov i iaitsevodov pri nalozhenii shvov (éksperimental'noe issledovanie).

A course of ultraphonophoresis of the extract of high-polar lipids of sulfide mud attenuated inflammation of uterine appendages in rats caused by catgut suturing of the ovaries and oviducts. On postoperative day 75-120 peloid therapy resulted in degradation of the suture material and its replacement with connective tissue. The peloid limited postoperative intensification of follicular atresia, raised content of growing follicles and yellow bodies in the ovaries.

[The ultrastructural changes to the ovaries and oviducts in experimental inflammation under the influence of eplir phonophoresis]. / Ul'trastrukturnye izmeneniia iaichnikov i iaitsevodov pri éksperimental'nom vospalenii pod vliianiem fonoforeza éplira.

Ultrastructural changes of blood vessels of ovaries and oviducts, destruction of the part of follicular epitheliocytes and disruption of other structures of blood-follicular barrier occur at the early period of experimental inflammations of appendage uterus on the background of traditional antibiotic therapy. All changes lead to atresia of growing follicules. Fibrotic-sclerotic changes develop on the 30th day and during later period. Course of eplir phonophoresis decreases ultrastructural disruptions of vessels, follicular apparatus of ovaries and oviducts epithelium. Effect of physiotherapy is manifested though activity of fibroclasts and macrophages, that regulate collagen production/resorption ratio thus preventing the development of fibrotic changes of ovary stroma and oviduct wall.

[An experimental validation of the use of the ultraphonophoresis of the mud preparation Eplir in inflammation of the uterine adnexa]. / Eksperimental'noe obosnovanie primeneniia ul'trafonoforeza griazevogo preparata "Eplir" pri vospalenii pridatkov matki.

Eplir ultraphonophoresis started on day 5 of experimental inflammation of the uterine appendages in the presence of antibacterial therapy reduces the severity of exudative processes, hemodynamic disorders, leukocytic infiltration, follicular atresia, prevents growth of connective tissue stroma.