[The effect of tactivin and levamisole on the development of toxic brain edema-swelling]. / Vliianie taktivina i levamizola na razvitie toksicheskogo oteka-nabukhaniia golovnogo mozga.

Edema-swelling of the brain (ESB) is among the urgent problems of modern medicine. The purpose of the research was the study of the effect of immunotropic agents on formation of the pathologic process. It was demonstrated on a model of toxic ESB that taktivin and levamisole possess antiedemic activity. The effect is dose-dependent and is determined by the structural characteristics of the drugs under study. Unlike taktivin, large doses of levamisole demonstrate synergism with the effect of the edematous factor.

[The effect of thymosin fractions on the development of compression edema-swelling of the brain]. / Vliianie fraktsii timozina na razvitie kompressionnogo oteka-nabukhaniia golovnogo mozga.

The search for pathogenetically drugs for the treatment and prevention of edema-swelling of the brain (ESB) is one of the urgent problems of modern biology and medicine. Immune reactions take part in the development of pathological reactions in ESB formation. The antiedemic action of drugs affecting simultaneously the processes in the nervous and immune systems was studied. Such properties are possessed by regular peptides--thymosin fractions. It was demonstrated on a model that the antiedemic effect of thymic peptides under study was due to the influence of the mediator systems: serotonin and adrenergic. The data obtained allowed the antiedemic mechanism of the effect of thymoptin to be associated with its immunostimulating effect. At the same time, the antiedemic effect of thymalin is not connected directly with the immunostimulating action of the drug.

[The effect of the delta sleep-inducing peptide on the development of toxic brain edema-swelling]. / Vliianie peptida, vyzyvaiushchego del'ta-son, na razvitie toksicheskogo oteka-nabukhaniia golovnogo mozga.

Antiedematic effects of the drugs are connected with their action on the mediator systems. DSIP has a wide range of modulatory effects on the brain mediator systems. DSIP antiedematic effect was studied on the toxic brain edema-swelling (BES) model. Physical characteristics of the nervous tissue such as thickness and wetness were used as evaluation criteria. According to the findings, the doses of 75-100 micrograms/kg DSIP were optimal. It is suggested that DSIP effect on BES is multicomponent and rather complicated. Inhibition of serotonin, noradrenaline and histamine systems and activation of GABA-ergic system by DSIP act as a possible antiedematic mechanism.

[Effect of etimizol on the development of cerebral edematous swelling]. / Vliianie étimizola na razvitie oteka-nabukhaniia golovnogo mozga.

It was shown in experiments on rats on models of toxic and traumatic edemas-swellings that etimizol (5 and 1 mg/kg) prevented changes in total content of water and the cerebral tissue density.

[Effect of phenothiazine derivatives on the development of experimental traumatic brain edema]. / Vliianie proizvodnykh fenotiazina na razvitie travmaticheskogo oteka golovnogo mozga v éksperimente.

The effect of levomepromazin, propazin, diprazin and dyphenhydramine on the development of traumatic edema of the brain has been studied. Phenothiazine derivatives with an unbranched dialkylaminoalkyl side chain at the nitrogen atom (propazin) have been found to produce the most remarkable antiedematic action. The drugs that have a branched dialkylaminoalkyl chain (levomepromazin, diprazin) do not return brain water content to normal.