RESUMEN
A study was made of the effects of isothiobarbamine and guthimine (10 and 50 mg/kg, respectively) on the content of cAMP and cGMP in the brain cortex (BC) and hippocamp under normal conditions and hypoxia. Isothiobarbamine did not change the content of both cyclic nucleotides under normoxia, whereas under hypoxia it reduced the level of the cyclic nucleotides in the BC and raised it in the hippocamp. Guthimine increased their content in the BC and did not change it in the hippocamp under normoxia, whereas under hypoxia it increased the cAMP content in the hippocamp and did not change it in the BC. The cGMP content descended in both the structures under study.
Asunto(s)
Encéfalo/efectos de los fármacos , AMP Cíclico/metabolismo , GMP Cíclico/metabolismo , Guaniltiourea/uso terapéutico , Hipoxia/tratamiento farmacológico , Tiopental/uso terapéutico , Tiourea/análogos & derivados , Animales , Encéfalo/metabolismo , Corteza Cerebral/metabolismo , Evaluación Preclínica de Medicamentos , Hipocampo/metabolismo , Hipoxia/metabolismo , Masculino , Ratas , Ratas EndogámicasRESUMEN
Infraslow electrical activity and brain temperature were recorded with implanted electrodes and differential thermocouples in rabbits. Stimulation of gyrus cinguli increased the amplitude of infraslow activity and reduced its frequency. Stimulation of the hypothalamus entailed both changes of the infraslow activity and raise of the brain temperature. The effects of stimulation were altered after administration of antihypoxants.