[Comprehensive analysis of the efficacy of personalized rehabilitation programs in patients with breast cancer]. / Kompleksnyi analiz effektivnosti personalizirovannykh programm reabilitatsii bol'nykh rakom molochnoi zhelezy.

The concept of the personalized rehabilitation is based on the principle of applying physical and rehabilitative medicine techniques depending on the factors that mostly influence on rehabilitation efficacy in a particular patient - determinant of effectiveness. Current achievements in the diagnosis and treatment of breast cancer (BC) significantly increased overall patients' life expectancy, updating rehabilitative treatment stage, which is often unmet. OBJECTIVE: To perform the comprehensive analysis of the efficacy of personalized rehabilitation programs in patients with BC. MATERIAL AND METHODS: The combined comparative multi-centre randomised trial of rehabilitation program efficacy in patients with breast cancer was done. The study included 219 patients aged from 30 to 45 years (median 39.4 year), who were divided into 2 groups. The rehabilitation by programs, that included current personalized rehabilitative techniques (RT) with proved efficiency, based on scientometrical analysis of evidential research was performed in the first group patients. In the second group aftercare was done according to the standard programs. The comprehensive evaluation of treatment efficacy was conducted in several stages: 1) performance analysis of rehabilitative programs; 2) verification of the effectiveness' determinant of rehabilitation; 3) factor analysis to assess the mechanisms of therapeutic effects in experimental groups; 4) comparative analysis of alternative strategies for selecting rehabilitation programs. RESULTS: The use of rehabilitative programs, based on recommended RT, changes the rehabilitation structure, significantly increasing its efficacy by 17%. Furthermore, the percentage of high-efficiency usage of this type programs increases by 17% compared with standard programs. The main determinants, affecting the efficacy of rehabilitation programs, based on selected RT, are anamnestic data, parameters of exercise tolerance and physical activity and ultrasound parameters of upper limb blood flow. The therapeutic effects of personalized rehabilitation programs are realized by correction of clinical rates, increasing exercise tolerance and physical activity, as well as psychophysiological parameters. CONCLUSION: The use of the evaluation system of anamnestic, clinical, functional and psychophysiological features of patient (the effectiveness' determinant) in realization of personalized rehabilitation programs for women with BC, allows to predict and manage the efficacy of RT applying.

[A word about V.S. Ulashchik (on the 80th anniversary of his birth)]. / Slovo o V.S. Ulashchike (k 80-letiyu so dnya rozhdeniya).

In the history of physiotherapy there are many outstanding names, one of which is the name of Acad. V.S. Ulashchik's name is one of them. The medical community knows V.S. Ulashchik as an outstanding scientist in the field of physiotherapy, regenerative and integrative medicine, organizer of health care, who made a huge contribution to the development, first of all, of national physiotherapy and balneology.

[High-intensity laser therapy in clinical medicine: scientometric analysis of evidence of effectiveness]. / Vysokointensivnaya lazeroterapiya v klinicheskoi meditsine: naukometricheskii analiz dokazatel'stv effektivnosti.

INTRODUCTION: High-intensity laser technologies are widely used in modern restorative medicine, and indications for their use are expanding annually. These technologies are effective, potentially safe methods of treating many diseases. with pronounced therapeutic effects. PURPOSE OF RESEARCH: Analysis of scientific evidence of the effectiveness and safety of high-intensity laser therapy in patients with various diseases. MATERIAL AND METHODS: A comprehensive scientometric analysis of evidence-based studies of the effectiveness and safety of high-intensity laser therapy methods was carried out according to electronic databases (Google scholar, PEDro, PubMed, Cochrane DATABASE) for the period from 2006 to 2021. RESULTS: High-intensity laser therapy has a wide range of significantly pronounced therapeutic effects. and it is an effective method of treating patients with various diseases. Various technologies and methods of its application are widely used in various fields of clinical medicine. Individually developed therapy protocols are needed, with optimal exposure parameters for each patient, intervals between procedures. CONCLUSION: It is advisable to develop more reliable and standard evaluation criteria, regular generalization and analysis of existing evidence, careful planning and implementation of further large-scale randomized controlled trials to study the effects of high-intensity laser radiation both as a single effect and as part of combinations with other treatment methods. The effectiveness of combination therapy requires further analysis in the course of conducting new benign clinical trials.

[Therapeutic effects of climototherapy: scientomatrical analysis of evidence-based studies]. / Lechebnye effekty klimatoterapii: naukometricheskii analiz dokazatel'nykh issledovanii.

OBJECTIVE: Scientometrical analysis of studies the use of climatotherapy methods and formulation of guidelines based on the evidence obtained during the analysis. MATERIAL AND METHODS: The article presents the data of scientometrical analysis of 40 publications on the use of climatotherapy in spa practice. RESULTS: Clinical effects and proposed mechanisms of action of the proven efficacy climatotherapy methods - aerotherapy, heliotherapy and thalassotherapy for the patients with various chronic diseases are presented. The clinical directions for the using of climatotherapy methods in climatic resorts are highlighted. CONCLUSIONS: Regular generalization and analysis of existing evidence-based studies is required, as well as the implementation of new high-quality randomized controlled clinical trials to study the effects of climate therapy on a wide range of patients with common socially significant diseases.

[Physical factors in the rehabilitation of patients with the consequences of spinal cord injuries: scientometric analysis of evidence-based research]. / Fizicheskie faktory v reabilitatsii patsientov s posledstviyami spinnomozgovoi travmy: naukometricheskii analiz dokazatel'nykh issledovanii.

PURPOSE OF THE STUDY: Conduct scientometric analysis of evidence-based studies of physical methods of treating patients with the spinal cord injury (SCI) consequences. MATERIAL AND METHODS: Data from a scientometric analysis of evidence-based studies published from January 2014 to December 2019 on the use of therapeutic physical factors in the rehabilitation of patients with SCI are presented in the article. RESULTS: Groups of effective technologies, including physical activity, pulsed electrotherapy and robotic mechanotherapy are identified. Significant effects of applied technologies in patients with spinal trauma are shown. Promising groups of physical therapies requiring additional evidence-based research are identified. Recommendations on the use of therapeutic physical factors in the treatment of patients with SCI are proposed. CONCLUSION: A trend towards an increase in the number of randomized controlled trials to assess the effectiveness and expand the range of physical and rehabilitation medicine technologies used in the rehabilitation of patients with SCI are identified. Monitoring of technologies with proven effectiveness is necessary to improve the quality of rehabilitation measures in patients with SCI.

[The gastroprotective action of acidic mineral water from the Azhyg-Sug source on the stress-induced injuries to the stomach of white rats]. / Gastroprotektivnoe deistvie kisloi mineral'noi vody istochnika Azhyg-Sug pri stress-indutsirovannom povrezhdenii zheludka u belykh krys.

BACKGROUND: The relevance of this study is determined by the need for the scientifically sound substantiation of the possibility for the use of acidic mineral waters in the treatment of digestive diseases taking into consideration their widespread application in ethnomedicine, in particular in the Republic of Tuva. AIM: The objective of the present study was to elucidate the gastroprotective action of acidic mineral water from the Azhyg-Sug source (Republic of Tyva) on the experimental animals as exemplified by the model of ulcerogenesis under the conditions of immobilization stress. MATERIAL AND METHODS: The experimental studies were carried out with the use of 32 white rats of the Wistar line. Ulcerogenesis was initiated by means of immobilization stress. We evaluated the pathomorphological characteristics of the gastric mucosa and the number of destructions based on the Pauls index. The state of the lipid peroxidation system and antioxidative protection were determined from the content of malon dialdehyde and reduced glutathione, extracellular catalase and superoxide dismutase activities in erythrocytes. RESULTS: The study has demonstrated that the mineral water from the Azhyg-Sug source slows down the development of the inflammatory and destructive necrotic processes in the mucosa of the stomach of albino rats. The depth of erosion in the animals receiving mineral water was 2.3 and 3.4 times lower than in the control animals (p≤0.05). The antioxidant effect of mineral water was confirmed by the 14-20% decrease of the MDA concentration as well as by the increase of the catalase and superoxide dismutase (SOD) activities by 21-25% and 20-30% respectively in comparison with the control animals. CONCLUSION: The Azhyg-Sug mineral water has the strong gastroprotective influence on the experimental animals having the induced neurogenic ulcer. One of the mechanisms underlying the gastroprotective action of the investigated mineral water arises from its ability to inhibit the processes of lipid peroxidation with the simultaneous enhancement of the activity of the antioxidant system of the organism.

[The planning and evaluation of the effectiveness of rehabilitation of the patients presenting with osteoarthritis: application of the core set of the International Classification of Functioning, Disability, and Health]. / Planirovanie i otsenka effektivnosti reabilitatsii bol'nykh osteoartrozom: ispol'zovanie bazovogo nabora Mezhdunarodnoi klassifikatsii funktsionirovaniya, ogranichenii zhiznedeyatel'nosti i zdorov'ya.

This article was designed to report the results of analysis of the comprehensive rehabilitation programs for the patients presenting with osteoarthritis. The analysis was based on the Core Set of the International Classification of Functioning, Disability and Health (ICF Core Set). The authors carried out the evaluation of the effectiveness of rehabilitation for two groups of the patients suffering from osteoarthritis who had previously undergone the combined treatment based at different healthcare facilities (an in-patient clinic, a spa and health resort). It was shown that the application of the ICF Core Set for the management of osteoarthritis may be helpful for the development of a comprehensive rehabilitation program, the distribution of various tasks between the professionals in the most optimal way, and the correct evaluation of the effectiveness of their accomplishment. The rehabilitation program elaborated based on the ICF Core Set made it possible to enhance the effectiveness of the cycle of the rehabilitation measures.

[The department of balneology and physical medicine of the S.M. Kirov's Military-medical academy 75 years anniversary].

The article highlights the history of the creation of the Department of balneology and physiotherapy at the S.M. Kirov Military-medical academy and the stages of its development. Employees of the Academy have a priority in the scientific substantiation of main principles of physical medicine and rehabilitation. They stood at the forefront of development of scientific schools and research institutions. The article presents the main achievements of the Department in academic, research and clinical work.

[Transcranial magneto- and electrostimulation in patients with obesity and erectile dysfunction].

The objective of the present study was to evaluate therapeutic efficiency of transcranial magnetotherapy (TcMT) and electric stimulation (ES) included in the combined treatment of 143 patients with erectile dysfunction (ED) and abdominal obesity. The majority of the patients had waist circumference over 102 cm. An AMO-ATOS complex was used to stimulate the hypothalamic region and other brain structures. Transdermal myostimulation of the abdominal and femoral regions was achieved with a Miovolna device. It was shown that both TcM and ES improved lipid metabolism and erectile function; moreover, they exerted hypotensive and sedative action. Specifically, the testosterone level in the patients increased by a mean of 27% compared with the pre-treatment values while the number of patients complaining of erectile dysfunction decreased by 31%.

[Many-level polysensory stimulation of brain functions by physical therapeutic agents].

A combination of physiotherapeutic methods for neurorehabilitative treatment has been developed and applied to the treatment of 576 patients with neurosurgical problems including the loss of brain functions as a sequel to nervous system lesions of traumatic, vascular, and other origin. Methodologically, this complex is adapted to the level and extent of the lesion and the character of regeneration of the nervous tissues. It implies many-level stimulation of neuroregeneration by syndromically and pathogenetically substantiated application of physical factors in the early post-injury and postoperative periods. The proposed approach allows the brain function to be completely restored by virtue of persistent compensatory changes in the nervous system. A combination of many-level magnetic, electrical, and laser stimulation is recommended to manage lesions in the speech, motor, and visual analyzers. Combined laser and differential electrostimulation may be prescribed to patients with nerve lesions, extremely high frequency therapy to those with epileptic syndrome, combined microwave therapy to cases with impairment of consciousness, and a variant of systemic UV irradiation with underwater shower-massaging for the treatment of vegetative and asthenic disturbances. Selected physiological aspects of the action of the above physical factors are specified. This physiotherapeutic system is protected by 20 RF patents of invention.

[Therapeutic effects of laser therapy in patients with silent myocardial ischemia].

The technique of registration of pain and vibration sensitivity providing early diagnosis of painless ischemic heart disease is described. Basing on evident pathogenetic direction of a therapeutic action of laser therapy to different links of pathogenesis of arterial hypertension and ischemic heart disease, therapeutic effects of laser therapy in patients with painless myocardial ischemia in combination with essential hypertension were studied.

Genetic determinants of efficiency of magnetic laser therapy of essential hypertension.

The efficiency of magnetic laser therapy was evaluated in patients with essential hypertension (stages I and II). The role of angiotensinogen, angiotensin-converting enzyme, type II bradykinin receptor, and endothelial nitrogen oxide synthetase gene polymorphism in the realization of hypotensive effect of magnetic laser therapy was evaluated. The hypotensive effect of magnetic laser therapy depends on the polymorphism of the studied genes and is maximum in patients with MM polymorphism of angiotensinogen gene and DD polymorphism of angiotensin-converting enzyme gene. Additive interaction between angiotensin-converting enzyme and angiotensinogen genes in the formation of hemodynamic effects of magnetic laser therapy was detected.