RESUMEN
Elucidation of the pharmacodynamic mechanisms of drugs capable of potentiating the effects of non-steroidal anti-inflammatory drugs is an important task. In this in vitro study, the ability of Traumeel S to influence the innate and acquired immunity was evaluated. Traumeel S was found to reduce activities of NADPH oxidase and neutrophil extracellular traps, as well as to evoke anti-inflammatory activity of lymphocyte subpopulations.
Asunto(s)
Antiinflamatorios no Esteroideos/farmacología , Antiinflamatorios/farmacología , Trampas Extracelulares/inmunología , Minerales/farmacología , NADPH Oxidasas/metabolismo , Extractos Vegetales/farmacología , Inmunidad Adaptativa/efectos de los fármacos , Antígenos HLA-DR/inmunología , Humanos , Inmunidad Innata/efectos de los fármacos , Inflamación/tratamiento farmacológico , Inflamación/patología , Leucocitosis/inmunología , Subgrupos Linfocitarios/inmunología , Neutrófilos/inmunología , Linfocitos T/inmunología , Receptor fas/análisisRESUMEN
Taban-Arshan extract decreased expression of T-lymphocyte activation markers, normalized T-cell-mediated immunity, and suppressed increased activity of natural killer receptors during culturing with lymphocytes of patients with atopic bronchial asthma. Taban-Arshan extract normalized activation processes in the B-cell immunity and stimulated expression of receptors of activation-induced apoptosis.