[Yimusake Tablet: safe and efficacious for premature ejaculation].

OBJECTIVE: To objectively evaluate the efficacy and safety of Yimusake Tablet in the treatment of premature ejaculation (PE) through a multi-centered large-sample trial. METHODS: We conducted a multi-centered, open, fixed-dose, and self-compared clinical trial among 300 patients with diagnosed PE. The trial lasted 12 weeks, including 4 weeks without any medication and 8 weeks of treatment with Yimusake Tablet, 2 pills (1 g) per night. We observed the intravaginal ejaculation latency time (IELT) before and after treatment, evaluated the safety of medication, and performed a questionnaire investigation on the patients' satisfaction. RESULTS: Of the 300 PE patients, 288 accomplished the clinical trial. The patients ranged in age from 22 to 60 years, averaging at 31.6 years. The mean IELT of the patient was 62.5 seconds at baseline, 168.9 seconds after 4 weeks of treatment with Yimusake Tablet, and 222.2 seconds after 8 weeks of medication. Among the 157 patients with normal erectile function (IIEF >21), the mean IELT was 71.4 seconds before treatment, 147.4 seconds after 4 weeks of medication, and 172.5 seconds after 8 weeks of medication. The patients' satisfaction was significantly increased after treatment. Those complicated by mild to moderate erectile dysfunction achieved different degrees of improvement in the IIEF-5 score, with a mean increase of 3.8. Only a few patients experienced mild adverse events, including constipation, dry mouth, nose bleeding, abdominal pain, and lumbosacral pain, which were all relieved without drug withdrawal. CONCLUSION: Yimusake Tablet is a safe and effective medicine for the treatment of PE.

Bipolar versus monopolar transurethral resection of prostate: pathologic study in canines.

OBJECTIVES: To compare the coagulation depth and pathologic changes of the prostate after bipolar and monopolar transurethral resection of the prostate (TURP) in a canine model. METHODS: The prostates of 25 dogs were treated in vivo with bipolar TURP (bipolar group, n = 12), monopolar TURP (monopolar group, n = 12), or sham operation (sham-operated group, n = 1). The prostate specimens were evaluated pathologically, and the depth of the coagulation zones was measured after the dogs were killed at 0, 7, 14, and 60 days postoperatively. RESULTS: At day 0, the coagulation zones of the bipolar group were deeper than those of the monopolar group (P <0.01). At 7 days postoperatively, the coagulation zones had become much thinner in both groups, and the coagulation zones of the monopolar group were thicker than those of the bipolar group (P <0.01). At 14 days, no significant differences were found between the two groups (P >0.05). The pathologic examinations revealed inflammatory reactions in the bipolar and monopolar groups at 0, 7, and 14 days postoperatively. Also, some glandular lumina were expanded and the epithelia destroyed beneath the coagulation zones. At 60 days, the coagulation zones had completely peeled off, and the urothelium had regenerated, covering the surgical wound. None of these pathologic changes were found in the sham-operated group. CONCLUSIONS: The results of our study have shown that the pathologic changes in the prostate after bipolar and monopolar TURP are similar. However, the intraoperative coagulation zones of bipolar TURP are deeper and become thinner early after the operation than those of monopolar TURP.