RESUMEN
We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.
Asunto(s)
Aconitum/química , Analgésicos/farmacología , Dolor/prevención & control , Convulsiones/prevención & control , Ácido Acético , Aconitina/análogos & derivados , Aconitina/aislamiento & purificación , Aconitina/farmacología , Alcaloides/aislamiento & purificación , Alcaloides/farmacología , Analgésicos/aislamiento & purificación , Animales , Animales no Consanguíneos , Artritis Experimental/inducido químicamente , Artritis Experimental/fisiopatología , Dipirona/farmacología , Adyuvante de Freund , Inyecciones Intraperitoneales , Ratones , Dolor/inducido químicamente , Dolor/fisiopatología , Extractos Vegetales/química , Ratas , Convulsiones/inducido químicamente , Convulsiones/fisiopatología , Vocalización Animal/efectos de los fármacosRESUMEN
We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect.
Asunto(s)
Aconitum/química , Antiinflamatorios/farmacología , Diterpenos/farmacología , Extractos Vegetales/farmacología , Animales , Animales no Consanguíneos , Antiinflamatorios/uso terapéutico , Diterpenos/uso terapéutico , Evaluación Preclínica de Medicamentos , Edema/inducido químicamente , Edema/tratamiento farmacológico , Miembro Posterior/efectos de los fármacos , Miembro Posterior/patología , Ratones Endogámicos CBA , Extractos Vegetales/uso terapéuticoRESUMEN
Experiments show that ethanol extracts prepared from the above-ground parts of Aconitum baicalensis and the above-ground parts and roots of Aconitum septentrionale L. suppressed the exudative and proliferative stages of model chronic inflammation. Both phytopreparations normalized some biochemical indices of the blood (total protein, seromucoids, firbinogen) altered by the inflammation.