RESUMEN
Osteoporosis is simulated in rats by chronic administration of omeprazole or serotonin for 6 months; investigated bone status in the model of liver fibrosis and the administration of serotonin against liver fibrosis. The following experimental groups of rats: with bilateral ovariectomy, with bilateral ovariectomy and administration of omeprazole, with the introduction of serotonin, with serotonin administration and bilateral ovariectomy, with model of liver fibrosis, with liver fibrosis model and administration of serotonin were used. The content of Ca, P, alkaline phosphatase, albumin, serum creatinine, and the content of Ca, P, Mg andFe in the bone was determined. It was found that the administration of mesenchymal stromal cells reduces the severity of osteoporosis. The effects of alfacalcidol on experimental osteoporosis was investigated. Introduction of alfacalcidol in all experimental groups increased the bone formation.
Asunto(s)
Conservadores de la Densidad Ósea/farmacología , Hidroxicolecalciferoles/farmacología , Trasplante de Células Madre Mesenquimatosas , Osteogénesis/efectos de los fármacos , Osteoporosis/sangre , Osteoporosis/terapia , Aloinjertos , Animales , Antiulcerosos/efectos adversos , Antiulcerosos/farmacología , Modelos Animales de Enfermedad , Femenino , Cirrosis Hepática/sangre , Cirrosis Hepática/inducido químicamente , Cirrosis Hepática/terapia , Metales/sangre , Omeprazol/efectos adversos , Omeprazol/farmacología , Osteoporosis/etiología , Ovariectomía , Fósforo/sangre , Ratas , Ratas Wistar , Serotonina/efectos adversos , Serotonina/farmacología , Agonistas de Receptores de Serotonina/efectos adversos , Agonistas de Receptores de Serotonina/farmacologíaRESUMEN
Osteoporosis was modeled in rats by chronic (6 months) treatment with omeprazole or serotonin, and bone tissue status was studied in experimental hepatic fibrosis and during serotonin treatment under conditions of hepatic fibrosis. Serum levels of calcium, phosphorus, alkaline phosphatase, albumins, and creatinine and bone tissue levels of calcium, phosphorus, magnesium, and iron were measured. Treatment with mesenchymal stem cells over 6 months reduced the severity of osteoporosis.
Asunto(s)
Cirrosis Hepática/terapia , Trasplante de Células Madre Mesenquimatosas , Osteoporosis/terapia , Serotonina/farmacología , Albúminas/metabolismo , Fosfatasa Alcalina/sangre , Animales , Densidad Ósea/efectos de los fármacos , Huesos/metabolismo , Huesos/patología , Calcio/sangre , Tetracloruro de Carbono , Creatinina/sangre , Femenino , Hierro/metabolismo , Cirrosis Hepática/inducido químicamente , Cirrosis Hepática/metabolismo , Cirrosis Hepática/patología , Magnesio/sangre , Omeprazol , Osteoporosis/inducido químicamente , Osteoporosis/metabolismo , Osteoporosis/patología , Fósforo/sangre , Ratas , Ratas WistarRESUMEN
The effect of honey and pollen for an experimental gastric ulcer in rats by electromyography was investigated Okabe ulcer by applying the 100% acetic acid in the gastric serosa was simulated. Honey and pollen prevent the development of painful gastric motility, which confirms its gastroprotective action.