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Correction for 'Fabrication of red blood cell membrane-camouflaged Cu2-xSe nanoparticles for phototherapy in the second near-infrared window' by Zhou Liu et al., Chem. Commun., 2019, 55, 6523-6526.
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Nucleus-targeting NPs based on RuO2 (RuO2NPs) were developed by controlling the size and the surface charge of nanoparticles (NPs). This study not only demonstrates a facile approach for the fabrication of ultrasmall CS-RuO2NPs with good biocompatibility and excellent photothermal properties but also their unique potential for the nucleus-targeted low-temperature PTT.
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Nanopartículas/química , Imagen Óptica , Óxidos/química , Técnicas Fotoacústicas , Rutenio/química , Temperatura , Núcleo Celular/efectos de los fármacos , Humanos , Rayos Infrarrojos , Células MCF-7 , Óxidos/farmacología , Tamaño de la Partícula , Fototerapia , Rutenio/farmacología , Propiedades de SuperficieRESUMEN
Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that photoredox catalysis can provide an oxygen-independent mechanism of action to combat this problem. We have designed a highly oxidative Ir(III) photocatalyst, [Ir(ttpy)(pq)Cl]PF6 ([1]PF6, where 'ttpy' represents 4'-(p-tolyl)-2,2':6',2''-terpyridine and 'pq' represents 3-phenylisoquinoline), which is phototoxic towards both normoxic and hypoxic cancer cells. Complex 1 photocatalytically oxidizes 1,4-dihydronicotinamide adenine dinucleotide (NADH)-an important coenzyme in living cells-generating NAD⢠radicals with a high turnover frequency in biological media. Moreover, complex 1 and NADH synergistically photoreduce cytochrome c under hypoxia. Density functional theory calculations reveal π stacking in adducts of complex 1 and NADH, facilitating photoinduced single-electron transfer. In cancer cells, complex 1 localizes in mitochondria and disrupts electron transport via NADH photocatalysis. On light irradiation, complex 1 induces NADH depletion, intracellular redox imbalance and immunogenic apoptotic cancer cell death. This photocatalytic redox imbalance strategy offers a new approach for efficient cancer phototherapy.
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Citocromos c/metabolismo , Neoplasias/metabolismo , Hipoxia Tumoral , Antineoplásicos/química , Antineoplásicos/farmacología , Biocatálisis , Muerte Celular/efectos de los fármacos , Complejos de Coordinación/química , Complejos de Coordinación/farmacología , Teoría Funcional de la Densidad , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Modelos Moleculares , Conformación Molecular , NAD/antagonistas & inhibidores , NAD/metabolismo , Neoplasias/patología , Oxidación-Reducción , Procesos Fotoquímicos , Hipoxia Tumoral/efectos de los fármacosRESUMEN
Ir(iii) complex modified gold nanorods, Ir@AuNRs, were developed as mitochondria-targeted theranostic nanoagents. Their hypoxia imaging and photothermal therapeutic properties were demonstrated in vitro and in vivo.
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Oro/uso terapéutico , Hipoxia/diagnóstico por imagen , Hipoxia/terapia , Iridio/uso terapéutico , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/terapia , Células A549 , Animales , Oro/química , Humanos , Hipertermia Inducida/métodos , Hipoxia/diagnóstico , Hipoxia/patología , Iridio/química , Neoplasias Pulmonares/patología , Ratones Desnudos , Mitocondrias/efectos de los fármacos , Mitocondrias/patología , Nanotubos/química , Imagen Óptica , Fototerapia/métodos , Nanomedicina Teranóstica/métodosRESUMEN
Cu2-xSe nanoparticles (Cu2-xSeNPs) were camouflaged with a red blood cell membrane (RBC) to create nanoparticles with improved biocompatibility, longer blood retention times, excellent absorption properties, superior photothermal conversion efficiency (67.2%) and singlet oxygen production capabilities for the synergistic photothermal and photodynamic therapy of cancer in the second near-infrared (NIR-II) window.
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Antineoplásicos/uso terapéutico , Membrana Eritrocítica/química , Nanopartículas/uso terapéutico , Neoplasias/tratamiento farmacológico , Animales , Antineoplásicos/síntesis química , Antineoplásicos/efectos de la radiación , Antineoplásicos/toxicidad , Línea Celular Tumoral , Cobre/química , Calor , Humanos , Hipertermia Inducida/métodos , Rayos Infrarrojos , Ratones , Nanopartículas/química , Nanopartículas/efectos de la radiación , Nanopartículas/toxicidad , Fotoquimioterapia/métodos , Células RAW 264.7 , Selenio/química , Oxígeno Singlete/metabolismo , Ensayos Antitumor por Modelo de XenoinjertoRESUMEN
To enhance the efficacy and optimize the treatment of cancers, the integration of multimodal treatment strategies leading to synergistic effects is a promising approach. The coassembly of multifunctional agents for systematic therapies has received considerable interest in cancer treatment. Herein, Ru(II) complex-functionalized single-walled carbon nanotubes (Ru@SWCNTs) are developed as nanotemplates for bimodal photothermal and two-photon photodynamic therapy (PTT-TPPDT). SWCNTs have the ability to load a great amount of Ru(II) complexes (Ru1 or Ru2) via noncovalent π-π interactions. The loaded Ru(II) complexes are efficiently released by the photothermal effect of irradiation from an 808 nm diode laser (0.25 W/cm(2)). The released Ru(II) complexes produce singlet oxygen species ((1)O2) upon two-photon laser irradiation (808 nm, 0.25 W/cm(2)) and can be used as a two-photon photodynamic therapy (TPPDT) agent. Based on the combination of photothermal therapy and two-photon photodynamic therapy, Ru@SWCNTs have greater anticancer efficacies than either PDT using Ru(II) complexes or PTT using SWCNTs in two-dimensional (2D) cancer cell and three-dimensional (3D) multicellular tumor spheroid (MCTS) models. Furthermore, in vivo tumor ablation is achieved with excellent treatment efficacy under a diode laser (808 nm) irradiation at the power density of 0.25 W/cm(2) for 5 min. This study examines an efficacious bimodal PTT and TPPDT nanoplat form for the development of cancer therapeutics.
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Hipertermia Inducida , Rayos Infrarrojos , Nanotubos de Carbono/química , Fotoquimioterapia , Rutenio/farmacología , Animales , Supervivencia Celular/efectos de los fármacos , Espectroscopía de Resonancia por Spin del Electrón , Endocitosis/efectos de los fármacos , Femenino , Células HeLa , Humanos , Ratones Desnudos , Nanotubos de Carbono/ultraestructura , Fotones , Oxígeno Singlete/química , Espectrofotometría Ultravioleta , Esferoides Celulares/efectos de los fármacos , Esferoides Celulares/patologíaRESUMEN
The design and development of functional hybrid nanomaterials is currently a topic of great interest in biomedicine. Herein we investigated the grafting of Ru(II) polypyridyl complexes onto gold nanospheres (Ru@AuNPs) to improve the particles' near infrared (NIR) absorption, and ultimately allow for application in photothermal cancer therapy. As demonstrated in this article, these ruthenium(II) complexes could indeed significantly enhance gold nanospheres' two-photon luminescence (PTL) intensity and photothermal therapy (PTT) efficiency. The best dual functional nanoparticles of this study were successfully used for real-time luminescent imaging-guided PTT in live cancer cells. Furthermore, in vivo tumor ablation was achieved with excellent treatment efï¬cacy under a diode laser (808 nm) irradiation at the power density of 0.8 W/cm(2) for 5 min. This study demonstrates that the coupling of inert Ru(II) polypyridyl complexes to gold nanospheres allows for the enhancement of two-photon luminescence and for efficient photothermal effect.