Mindful eating questionnaire: Validation and reliability in Brazilian adults with type 2 diabetes mellitus.

OBJECTIVE: The objective was to evaluate the psychometric properties of the Mindful Eating Questionnaire (MEQ) in Brazilian subjects with type 2 diabetes mellitus (T2DM) and validate a Brazilian version of the MEQ for adults with T2DM (MEQ-DM). METHODOLOGY: Baseline data from the multicentre Nutritional Strategy for Glycaemic Control in Patients with Type 2 Diabetes Mellitus (NUGLIC) trial were used. Construct validity was assessed using exploratory factor analysis (EFA). The root mean square error of approximation (RMSEA), comparative fit index (CFI) and Tucker‒Lewis index (TLI) fit indices indicated the adequacy of the model. The reliability of the questionnaire was evaluated considering the different factor loadings. Criterion validity was tested by correlating the MEQ-DM with sociodemographic variables, body mass index (BMI) and physical activity levels. RESULTS: A total of 370 participants were included, who were mostly female (60.8 %) and had a median age of 61 (54-67) years. The EFA results supported the two-factor structure of the 25-item MEQ-DM: disinhibition and awareness. The results of the fit indices (RMSEA = 0.04; CFI = 0.95 and TLI = 0.94) and composite reliability (disinhibition = 0.84 and awareness = 0.81) were consistent. The criterion validity analysis indicated a significant association between MEQ-DM scores and age, sex, civil status, education level, BMI and physical activity (p < 0.05). CONCLUSION: When explored with Brazilian adults with T2DM, the MEQ-DM presented a factorial model with two dimensions: disinhibition and awareness. This model must be confirmed in future studies with Brazilians with T2DM.

Mindfulness Practice for Glycemic Control: Could it be a New Strategy for an Old Problem? A Systematic Review and Meta-Analysis.

BACKGROUND: The management of type 2 diabetes mellitus (T2DM) requires a complex and organized care that includes patient's lifestyle change. Additionally, emotional well-being is an important part of self-management, and it may impair the individual's adherence. Therefore, equipping the patients with the necessary coping and self-care techniques may be an important step in managing diabetes. OBJECTIVE: To evaluate the effect of interventions using established mindfulness-based protocols on glycemic control of individuals with T2DM. METHODS: Data sources: Two electronic databases (PubMed and EMBASE) were searched from inception to December 2019. We limited our search to published studies in English, Spanish and Portuguese languages. STUDY SELECTION: Randomized clinical trials that assessed the effects of mindfulness in individuals with T2DM were selected. DATA EXTRACTION: Two authors independently assessed the risk of bias and extracted data from the included trials. Data were pooled using inverse-variance random-effects meta-analyses. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. RESULTS: Four randomized trials were included. There were no differences in blood glucose change (mean difference between groups (MD) -0.73mg/dl; 95% CI, -10.49; 9.02; I2 =0%; very low quality of evidence) or glycated hemoglobin (MD 0.05%; 95%CI -0.22 to 0.32; I2 =29%; very low quality of evidence). CONCLUSION: Although the quality of current evidence is very low, our findings suggest that established protocols involving mindfulness have no effect on blood glucose or glycated hemoglobin in individuals with T2DM. Indeed, large-scale trials are needed to evaluate the contribution of mindfulness to glycemic control in clinical practice. PROSPERO Registration ID: RD42020161940.

Efetividade de uma intervenção baseada em Mindfulness para redução de estresse e melhora da qualidade de vida em estudantes de enfermagem: Effects on stress and quality of life / Mindfulness based intervention for nursing students / Efectividad de una intervencion basada en Mindfulness para reduccion de estres y mejora de la calidad de vida en estudiantes de enfermeria

OBJETIVO: avaliar a efetividade de uma intervenção para redução de estresse baseada em Mindfulness em aspectos relacionados à Qualidade de Vida, Atenção Plena e Estresse Percebido, em estudantes de graduação e pós-graduação em enfermagem. MÉTODO: aplicados instrumentos de avaliação para a construção de uma linha basal e posteriormente a amostra foi submetida a um Programa de Redução de Estresse e aumento da Qualidade de Vida baseado em Mindfulness, formatado em encontros semanais por oito semanas. RESULTADOS: após a intervenção, houve diminuição do nível de Estresse Percebido, aumento do nível de Atenção Plena e melhora da Qualidade de Vida em âmbito psicológico. CONCLUSÃO: intervenções baseadas em Mindfulness se mostram efetivas e podem constituir um importante recurso para o gerenciamento do estresse e melhora na Qualidade de Vida dos estudantes.

OBJECTIVE: to evaluate the effectiveness of an intervention to reduce stress based on Mindfulness in aspects related to Quality of Life, Mindfulness and Perceived Stress in undergraduate and postgraduate students of Nursing. METHOD: evaluation instruments were applied to establish baseline data, and the sample was subsequently submitted to a Mindfulness Based Stress Reduction and Quality of Life, formatted eight consecutive weeks. RESULTS: after the intervention, there was a decrease in the level of Perceived Stress, increase in the level of Mindfulness and improvement of the Quality of Life in the psychological area. CONCLUSION: interventions based in Mindfulness are effective and can offer important resources for managing stress and improving the Quality of Life of students.

OBJETIVO: evaluar la efectividad de una intervención para reducción de estrés basada en Mindfulness en relación a la Calidad de Vida, Atención Plena y Estrés Percibido, en universitarios y estudiantes de postgrado de Enfermería. MÉTODO: previamente se aplicaron instrumentos de evaluación para la construcción de una línea basal y posteriormente la muestra fue sometida a un Programa de Reducción de Estrés y aumento de la Calidad de Vida basado en Mindfulness, constituído de encuentros semanales, durante ocho semanas consecutivas. RESULTADOS: se observó que después de la intervención, hubo disminución del nivel de Estrés Percibido, aumento del nivel de Atención Plena y mejora de la Calidad de Vida en ámbito psicológico. CONCLUSIÓN: intervencones basadas en Mindfulness se muestran efectivas y pueden constituir un importante recurso para manejar el estrés y mejorar la Calidad de Vida de los estudiantes.

Criação do Centro Brasileiro de Mindful Eating: resgate da consciência e do amor ao comer / Creation of the Brazilian Center of Mindful Eating: recovery of conscience and love when eating / Creación del Centro Brasileño de Mindful Eating: el rescate de la conciencia y del amor al comer

OBJETIVO: descrever a trajetória da criação do Centro Brasileiro de Mindful Eating e buscar compreender as motivações, os objetivos, os resultados já alcançados e as perspectivas e desafios para o futuro dessa organização. MÉTODO: estudo descritivo, exploratório com delineamento qualitativo. A coleta de dados foi realizada por meio de consultas aos documentos disponíveis no site do Centro e relatos de profissionais envolvidos em sua idealização e criação. As informações reunidas foram organizadas em categorias temáticas para oferecer descrição consistente do referido Centro enquanto marco referencial para o movimento científico e profissional do comer consciente. RESULTADOS E DISCUSSÃO: a criação do Centro compreendeu: Organização e estrutura: independência, descentralização e horizontalidade; Objetivos e motivações: amor, cuidado e ética; Desafios e perspectivas futuras: plantar, cuidar e colher. Tais categorias, exploradas em conjunto, revelaram a importância da criação do Centro ao colaborar, entre outras questões, para o estabelecimento do tema no Brasil. CONCLUSÃO: o Centro tem colaborado para o desenvolvimento profissional ético dessa área de conhecimento no Brasil, estabelecendo-se no sentido de organizar e oferecer referência para disseminação das referidas práticas. Estudos baseados nessa temática poderão contribuir para que o Mindful Eating se fortaleça enquanto importante recurso para a saúde e qualidade de vida.

OBJECTIVE: to describe the trajectory of the creation of the Brazilian Center of Mindful Eating and to attempt to understand the motivations, objectives, the already obtained results, as well as the future perspectives and challenges of this organization. METHOD: exploratory descriptive study with a qualitative design. Data collection was carried out by consulting the documents available on the Center's website and compiling the accounts given by the professionals involved in conceiving and creating the Center. The obtained information was sorted into categories so as to provide a consistent description of said Center as a milestone for the mindful eating scientific and professional movement. RESULTS AND DISCUSSION: creating the Center required: Organization and structure: independence, decentralization and horizontality; Objectives and motivations: love, care and ethics; Challenges and future perspectives: cultivating, taking care of and reaping the benefits of it. Those categories, explored together, have shown how important it was to create the Center to cooperate, among other things, to inaugurate the topic in Brazil. CONCLUSION: the Center has been contributing to the ethical professional development of this field of knowledge in Brazil and has been establishing itself so as to organize and be the reference to disseminate such practices. Studies based on this subject may contribute to strengthen Mindful Eating as an important resource for health and quality of life.

OBJETIVO: describir la trayectoria de la creación del Centro Brasileño de Mindful Eating y buscar comprender los motivos, los objetivos, los resultados ya alcanzados y las perspectivas y desafíos para el futuro de esta organización. METODOLOGIA: estudio descriptivo, exploratorio con enfoque cualitativo. La recolección de datos se realizó a través de consultas a los documentos disponibles en la página web del Centro y relatos de profesionales involucrados en su creación. La información recabada fue organizada en categorías temáticas para ofrecer una descripción consistente de dicho Centro como marco referencial para el movimiento científico y profesional del comer consciente. RESULTADOS Y DISCUSIÓN: la creación del Centro involucró: Organización y estructura: independencia, descentralización y horizontalidad; Objetivos y motivos: amor, cuidado y ética; Desafíos y perspectivas futuras: plantar, cuidar y cosechar. Tales categorías, exploradas en conjunto, han revelado la importancia de la creación del Centro al colaborar, entre otros aspectos, al desarrollo de este tema en Brasil. CONCLUSIÓN: el Centro ha contribuido al desarrollo profesional y ético de esta área de conocimiento en Brasil, estableciéndose a modo de organizar y servir de referencia para la difusión de tales prácticas. Los estudios con base en este tema podrán ayudar a que el Mindful Eating se fortalezca como un importante recurso para la salud y la calidad de vida.

Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women.

INTRODUCTION: Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation. There is a lot of evidence that some polyphenols, such as green tea, have a positive impact on the OS state and consecutively, on inflammation. Objectives: the purposes of this study were: a) evaluate OS biomarkers in both obese and normal weight women; and b) evaluate if green tea supplementation has an impact on OS and inflammatory cytokine biomarkers of obese women. Methods: we evaluated obese (body mass index [BMI] ≥ 40 kg/m²) and normal weight (BMI between 18.5 and 24.9 kg/m²) women. Blood samples were used to access malondialdehyde (MDA), trolox equivalent antioxidant capacity (TEAC) and inflammatory cytokines. We randomly chose obese patients (18 individuals) and then gave them green tea supplementation for eight weeks. Statistical analysis included the Shapiro-Wilk, Wilcoxon, independent and paired t tests; p < 0.05 were considered as significant. Results: we enrolled 42 obese (BMI: 48.2 ± 9.3kg/m2) and 21 normal weight (BMI: 22.5 ± 2 kg/m2) women with an average age of 36.2 ± 9.1 years old. The serum levels of MDA were higher in obese (2.52 ± 0.31 µmol/l) than in eutrophic women (2.13 ± 0.26 µmol/l; p = 0.000). On the other hand, lower TEAC values were observed in the obese (0.75 ± 0.06 mM/l) than in the eutrophic group (0.78 ± 0.04 mM/l; p = 0.009). After the green tea intervention, MDA decreased 4.7% and TEAC increased 10%. Interleukin-6 (IL-6) serum levels decreased 12.7% after treatment (p = 0.03). Conclusions: a) the obese group had lower antioxidant capacity than eutrophic; and b) green tea supplementation ameliorated TEAC and MDA and reduced serum levels of IL-6 in obese women.

INTRODUCCIÓN: Introducción: la obesidad se asocia con altos niveles de estrés oxidativo (EO) e inflamación. Existe mucha evidencia de que algunos polifenoles, como el té verde, tienen un impacto positivo en el estado del EO y, consecutivamente, en la inflamación. Objetivos: los propósitos de este estudio fueron: a) evaluar los biomarcadores de EO en mujeres obesas y de peso normal; y b) evaluar si la suplementación con té verde tiene un impacto en el EO y biomarcadores de citoquinas inflamatorias de las mujeres obesas. Métodos: evaluamos mujeres obesas (índice de masa corporal [IMC] ≥ 40 kg/m²) y con peso normal (IMC entre 18,5 y 24,9 kg/m²). Se utilizaron muestras de sangre para determinar el malondialdehído (MDA), la capacidad antioxidante equivalente de trolox (TEAC) y las citoquinas inflamatorias. Elegimos al azar pacientes obesas (18 individuos) y luego les dimos suplementos de té verde durante ocho semanas. El análisis estadístico incluyó las pruebas de Shapiro-Wilk, Wilcoxon, t pareadas e independientes; p < 0,05 fueron considerados como significativos. Resultados: se reclutaron 42 mujeres obesas (IMC: 48,2 ± 9,3 kg/m2) y 21 de peso normal (IMC: 22,5 ± 2 kg/m2) con un promedio de edad de 36,2 ± 9,1 años. Los niveles séricos de MDA fueron más altos en las personas obesas (2,52 ± 0,31 µmol/L) que en las mujeres eutróficas (2,13 ± 0,26 µmol/L; p = 0,000). Por otro lado, se observaron valores TEAC más bajos en los obesos (0,75 ± 0,06 mM/L) que en el grupo eutrófico (0,78 ± 0,04 mM/L; p = 0,009). Después de la intervención con té verde, la MDA disminuyó 4.7% y el TEAC aumentó 10%. Los niveles séricos de interleucina-6 (IL-6) disminuyeron 12.7% después del tratamiento (p = 0,03). Conclusiones: a) mujeres obesas tienen menor capacidad antioxidante que las eutrófica; y b) la suplementación con té verde mejora TEAC y MDA y redujo los niveles séricos de IL-6 en mujeres obesas.

Impact of green tea epigallocatechin-3-gallate on HIF1-α and mTORC2 expression in obese women: anti-cancer and anti-obesity effects?

INTRODUCTION: Introduction: epigallocatechin-3-gallate (EGCG) is the most abundant catechin contained in green tea (Camellia sinensis) and has been associated with anti-obesity and anti-cancer effects, but the exact molecular mechanisms remain elusive. In this context, this study was designed to improve the understanding of the EGCG anti-obesity and anti-cancer action. Objectives: this study was designed to examine the effects of EGCG on the expression of genes involved in obesity and cancer pathways in the peripheral blood mononuclear cells of obese women. Material and methods: this longitudinal interventional study enrolled eleven women with severe obesity that were submitted to eight weeks of green tea (decaffeinated green tea capsules with 450.7 mg of EGCG, two capsules/day) supplementation (intervention group) and ten eutrophic women as a control group. Weight (kg), body mass index (BMI, kg/m2), fat mass (kg) and gene expression (qPCR method) were assessed before and after supplementation. HIF1-alpha (HIF1-α), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and rapamycin-insensitive companion of mTOR (RICTOR) were selected as potential targets. Results: after supplementation, body weight (114.9 ± 14.3 versus 115 ± 13.8 kg), body mass index (44.1 ± 3.7 versus 44.1 ± 3.9 kg/m2) and fat mass (47.6 ± 3.3 versus 47.3 ± 3.4 kg) did not change. EGCG upregulated the RICTOR and HIF1-α expression, however, did not modify PI3K expression. Conclusion: this study demonstrated that EGCG has a potential role to obesity and cancer related to obesity control and can be used not only for the purpose of weight loss, but also for the improvement of obesity-related comorbidities.

INTRODUCCIÓN: Introducción: la obesidad se asocia con altos niveles de estrés oxidativo (EO) e inflamación. Existe mucha evidencia de que algunos polifenoles, como el té verde, tienen un impacto positivo en el estado del sistema operativo y consecutivamente en la inflamación. Objetivos: los propósitos de este estudio fueron: a) acceso a biomarcadores de EO en mujeres obesas y de peso normal; y b) evaluar si la suplementación con té verde tiene impacto en los biomarcadores de citoquinas inflamatorias y de EO de mujeres obesas. Métodos: evaluamos mujeres obesas (índice de masa corporal - IMC ≥ 40 kg/m²) y peso normal (IMC entre 18,5 y 24,9 kg/m²). Se utilizaron muestras de sangre para acceder al malondialdehído (MDA), la capacidad antioxidante equivalente de Trolox (TEAC) y las citoquinas inflamatorias. Elegimos al azar pacientes obesos (18 individuos) y luego les dimos suplementos de té verde durante 8 semanas. El análisis estadístico incluyó las pruebas de Shapiro-Wilk, Wilcoxon, t pareadas e independientes, p < 0,05 se consideraron significativas. Resultados: se reclutaron 42 mujeres obesas (IMC: 48,2 ± 9,3 kg/m2) y 21 de peso normal (IMC: 22,5 ± 2 kg/m2) con una edad promedio de 36,2 ± 9,1 años. Los niveles séricos de MDA fueron más altos en las personas obesas (2,52 ± 0,31 µmol/L) que en las mujeres eutróficas (2,13 ± 0,26 µmol/L; p = 0.000). Por otro lado, se observaron valores de TEAC más bajos en obesos (0,75 ± 0,06 mM) que en el grupo eutrófico (0,78 ± 0,04 mM; p = 0,009). Después de la intervención del té verde, la MDA disminuyó 4,7% y el TEAC aumentó 10%. Los niveles séricos de interleucina-6 (IL-6) disminuyeron 12,7% después del tratamiento (p = 0,03). Conclusiones: el grupo obeso tenía menor capacidad antioxidante que el eutrófico. La suplementación con té verde mejoró TEAC y MDA y redujo los niveles séricos de IL-6 en mujeres obesas.

Green tea supplementation promotes leukocyte telomere length elongation in obese women.

INTRODUCTION: inflammation and oxidative stress are factors that may play a substantial role in telomere attrition. In line of this, obesity is associated with telomere shortening. Green tea had anti-inflammatory and antioxidant effects and may alter telomere length (TL). OBJECTIVES: we evaluated the effect of decaffeinated green tea supplementation in obese women on TL. METHODS: we conducted a cross-sectional interventional study with ten obese (body mass index [BMI] > 40 kg/m²) and eight normal weight (BMI > 18.5 and < 24.9 kg/m²) women (age between 27 and 48 years). The supplementation was carried out with capsules (each contained 450.7 mg of epigallocatechin-3-gallate) during eight weeks. Anthropometric and dietary intake assessment, and blood collection (for biochemical and TL analysis by quantitative PCR) were performed before and after supplementation. Normal weight patients were evaluated at a single moment. RESULTS: we observed a significant increase on TL after supplementation (1.57 ± 1.1 to 3.2 ± 2.1 T/Sratio; p < 0.05). Moreover, we found shorter TL in obese patients (day 0) when compared to normal weight individuals (3.2 ± 1.9 T/Sratio; p < 0.05) and an inverse association between TL and BMI, even after age adjustment (beta = -0.527; r² = 0.286; IC = -0.129, -0.009). CONCLUSION: obesity is related to shorter telomeres. Green tea supplementation during eight weeks promotes telomere elongation in obese women.

Green tea supplementation upregulates uncoupling protein 3 expression in severe obese women adipose tissue but does not promote weight loss.

This study aims (i) to verify expression of the UCPs, PLIN1, PPARG2, and ADRB3 genes in the abdominal subcutaneous adipose tissue of obese women at baseline and after 8 weeks of supplementation with decaffeinated green tea extract, and (ii) to associate findings with clinical parameters. This is a longitudinal study during which 11 women with obesity grade III were submitted to supplementation with 450 mg of (-)-epigallocatechin gallate (EGCG) (intervention group); the control group consisted of 10 eutrophic women. Anthropometric parameters [weight, height, and body mass index (BMI)], resting metabolic rate (RMR, measured by indirect calorimetry), and gene expression (measured by real-time PCR, RT-qPCR) were determined before and after supplementation. After 8 weeks, clinical parameters and UCP1, PLIN1, PPARG2, and ADRB3 expression remained unaltered in the intervention group (p > .05). Genetic analysis also showed that the UCP3 gene was upregulated (p = .026), but its upregulation did not promote weight loss.