1.
Bioorg Med Chem
; 11(23): 5025-33, 2003 Nov 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-14604665
RESUMEN
Mono- and bis-benzo[b]oxepine derivatives have been rationally synthesized to meet the molecular requirement for interaction with estrogen receptor. Bis-benzo[b]oxepines (7 and 9) and mono-benzo[b]oxepine (10) acquire geometry with phenolic groups disposed in a fashion to stimulate estrogen receptor. Structure-based investigation, in vivo activity and docking studies have been described and correlated to demonstrate a practical approach for suitable ligand design.