RESUMEN
Correction for 'Fabrication of red blood cell membrane-camouflaged Cu2-xSe nanoparticles for phototherapy in the second near-infrared window' by Zhou Liu et al., Chem. Commun., 2019, 55, 6523-6526.
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Nucleus-targeting NPs based on RuO2 (RuO2NPs) were developed by controlling the size and the surface charge of nanoparticles (NPs). This study not only demonstrates a facile approach for the fabrication of ultrasmall CS-RuO2NPs with good biocompatibility and excellent photothermal properties but also their unique potential for the nucleus-targeted low-temperature PTT.
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Nanopartículas/química , Imagen Óptica , Óxidos/química , Técnicas Fotoacústicas , Rutenio/química , Temperatura , Núcleo Celular/efectos de los fármacos , Humanos , Rayos Infrarrojos , Células MCF-7 , Óxidos/farmacología , Tamaño de la Partícula , Fototerapia , Rutenio/farmacología , Propiedades de SuperficieRESUMEN
Photodynamic therapy (PDT) is a treatment procedure that relies on cytotoxic reactive oxygen species (ROS) generated by the light activation of a photosensitizer. The photophysical and biological properties of photosensitizers are vital for the therapeutic outcome of PDT. In this work a 2D rhomboidal metallacycle and a 3D octahedral metallacage were designed and synthesized via the coordination-driven self-assembly of a Ru(II)-based photosensitizer and complementary Pt(II)-based building blocks. The metallacage showed deep-red luminescence, a large 2-photon absorption cross-section, and highly efficient ROS generation. The metallacage was encapsulated into an amphiphilic block copolymer to form nanoparticles to encourage cell uptake and localization. Upon internalization into cells, the nanoparticles selectively accumulate in the lysosomes, a favorable location for PDT. The nanoparticles are almost nontoxic in the dark, and can efficiently destroy tumor cells via the generation of ROS in the lysosomes under 2-photon near-infrared light irradiation. The superb PDT efficacy of the metallacage-containing nanoparticles was further validated by studies on 3D multicellular spheroids (MCS) and in vivo studies on A549 tumor-bearing mice.
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Nanopartículas del Metal , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/farmacología , Compuestos de Platino , Compuestos de Rutenio , Células A549 , Animales , Desarrollo de Medicamentos , Humanos , Lisosomas , Ratones , Neoplasias Experimentales/tratamiento farmacológico , Fármacos Fotosensibilizantes/químicaRESUMEN
Ir(iii) complex modified gold nanorods, Ir@AuNRs, were developed as mitochondria-targeted theranostic nanoagents. Their hypoxia imaging and photothermal therapeutic properties were demonstrated in vitro and in vivo.
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Oro/uso terapéutico , Hipoxia/diagnóstico por imagen , Hipoxia/terapia , Iridio/uso terapéutico , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/terapia , Células A549 , Animales , Oro/química , Humanos , Hipertermia Inducida/métodos , Hipoxia/diagnóstico , Hipoxia/patología , Iridio/química , Neoplasias Pulmonares/patología , Ratones Desnudos , Mitocondrias/efectos de los fármacos , Mitocondrias/patología , Nanotubos/química , Imagen Óptica , Fototerapia/métodos , Nanomedicina Teranóstica/métodosRESUMEN
Cu2-xSe nanoparticles (Cu2-xSeNPs) were camouflaged with a red blood cell membrane (RBC) to create nanoparticles with improved biocompatibility, longer blood retention times, excellent absorption properties, superior photothermal conversion efficiency (67.2%) and singlet oxygen production capabilities for the synergistic photothermal and photodynamic therapy of cancer in the second near-infrared (NIR-II) window.