1.
Bioorg Med Chem Lett
; 26(3): 936-940, 2016 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26747393
RESUMEN
Herein, we describe the synthesis, antiviral structure-activity relationships (SAR), metabolic stability, and pharmacokinetic (PK) properties for a series of cyclopropylindolobenzazepine acylsulfonamide HCV NS5B polymerase inhibitors. Optimization of SAR, metabolic stability and PK led to the identification of compound 19 which was advanced into pre-IND enabling toxicology studies.