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Toxicol Ind Health ; 33(2): 119-132, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26431867

RESUMEN

Silica nanoparticles (SiNPs) are being used increasingly in biomedical and industrial fields; however, their adverse effects on human health have not been fully investigated. In this study, we focused on some of the toxicological aspects of SiNPs by studying oxidative stress and pro-inflammatory responses in the frontal cortex, corpus striatum and hippocampus regions of rat brain. Wistar rats were exposed to SiNPs of size 80 nm and 10 nm at a dose of 150 µg/50 µL phosphate-buffered saline/rat for 30 days. The results indicated a significant increase of lipid peroxide levels and hydrogen peroxide content in various regions of the treated rat brain. Moreover, these changes were accompanied with a significant decrease in the activities of manganese superoxide dismutase, glutathione reductase, catalase and reduced glutathione in different brain regions, suggesting impaired antioxidant defence system. Furthermore, SiNPs exposure not only increased messenger RNA (mRNA) and protein expression of nuclear factor-κB (NF-κB) but also significantly increased the mRNA and protein levels of tumour necrosis factor α (TNF-α), interleukin 1ß (IL-1ß) and monocyte chemoattractant protein 1 (MCP-1) in different regions of rat brain. Cumulatively, these data suggest that SiNPs induced the activation of NF-κB and increased the expression of TNF-α, IL-1ß and MCP-1 in rat brain, possibly via redox-sensitive cellular signalling pathways.


Asunto(s)
Encéfalo/efectos de los fármacos , Nanopartículas/efectos adversos , Dióxido de Silicio/efectos adversos , Administración Intranasal , Animales , Cuerpo Estriado/química , Cuerpo Estriado/efectos de los fármacos , Lóbulo Frontal/química , Lóbulo Frontal/efectos de los fármacos , Hipocampo/química , Hipocampo/efectos de los fármacos , Peróxido de Hidrógeno/análisis , Inflamación/inducido químicamente , Peroxidación de Lípido/efectos de los fármacos , Masculino , Nanopartículas/administración & dosificación , Estrés Oxidativo/efectos de los fármacos , Ratas , Ratas Wistar , Reacción en Cadena en Tiempo Real de la Polimerasa , Dióxido de Silicio/administración & dosificación , Superóxido Dismutasa/metabolismo
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