The current role of Astym therapy in the treatment of musculoskeletal disorders.

Background: In general, chronic problems of soft tissues (muscles, tendons, ligaments) are due to scarring or degeneration. Astym therapy (Performance Dynamics, Inc. Muncie, Indiana) has been reported to address tendinopathy by stimulating regeneration in soft tissues (muscles, tendons, ligaments) and the resorption of unwanted scar tissue that causes pain and limits mobility.Purpose: To analyze the effectiveness of Astym therapy in the treatment of musculoskeletal problemsMethods: A narrative review of the literature on the topic was carried out. A Cochrane Library and PubMed (MEDLINE) search related to the role of Astym therapy was analyzed. The only language searched was English. Scientific meeting abstracts and other sources of evidence were not considered. The main criteria for selection were articles that were focused on the role of Astym therapy.Results: Astym therapy seems to be useful for the treatment of chronic ankle sprains, Achilles tendon tendinopathy, hamstring tendinopathy, elbow tendinopathy, and the stiff total knee arthroplasty. Astym therapy also appears to be useful to gain range of motion, muscle strength, and function in patients with cerebral palsy, and after mastectomy.Conclusions: Astym therapy seems to activate a regenerative response in degenerative tendinopathy and eliminate or reduce the scar tissue/fibrosis that causes pain and limitation of mobility. Based on the positive findings of the emerging published research further study is warranted to confirm the benefits of Astym therapy on a variety of musculoskeletal disorders.

A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal.

This work assessed the antioxidant potential, acetylcholinesterase (AChE) inhibition and the in vitro cytotoxic activity of extracts of the seagrasses Zostera marina and Zostera noltei collected from southern Portugal. The total phenolic contents (TPCs), the rosmarinic acid (RA) concentration (HPLC/DAD) and the fatty acid (FA) profile (GC/MS) are also described. Z. marina had the highest TPC, radical scavenging activity against DPPH radicals and copper chelating activity. Z. noltei had metal chelation capacity to copper and iron ions. None of the species was able to inhibit AChE. Both seagrasses had high levels of polyunsaturated FAs. Z. marina significantly and selectively reduced the viability of tumorous neuronal cells. Z. noltei was highly toxic for the three cell lines tested and was selective against hepatocarcinoma cells at the concentration of 100 µg/mL. RA was the main compound identified in Z. marina, but not in Z. noltei.

The role of physical medicine and rehabilitation in haemophiliac patients.

Physical medicine and rehabilitation aim to evaluate, diagnose and treat disability in haemophiliac patients, while preventing injury or deterioration. They also aim to maintain the greatest degree of functional capacity and independence in patients with haemophilia, or to return them to that state. Rehabilitation, together with clotting factor replacement therapy, has revolutionized the management of these patients in developed countries and reduced their morbidity/mortality rates. A knowledge of the musculoskeletal signs and symptoms of haemophilia is essential for providing a treatment which is suitable and customized. Physical medicine and rehabilitation techniques, which are based on physical means, are intended to reduce the impact which these injuries and their consequences or sequelae can have on the quality of life of patients with haemophilia. Under ideal haemostatic control conditions (primary prophylaxis), people with haemophilia could achieve good physical condition which will allow them to enjoy both physical activity and a daily life without limitations. Currently, children undergoing primary prophylaxis are quite close to this ideal situation. For these physical activities to be carried out, the safest possible situations must be sought.

Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).

The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.