RESUMEN
One of the disadvantages of photodynamic therapy is impossibility to specify the method according to biological features of malignant tumor such as a degree of blood supply, accumulation of photosensibilizator in tumorous tissue, proliferative activity and etc. The authors aimed to develop a mode of individualization of endobronchial photodynamic therapy of central non-small cell carcinoma of lung and assessment of method efficacy. The suggested method is based on fluorescent diagnostics of degree of accumulation of photosensibilizator in timorous tissue and the rate of its expenditure in process of performing of photodynamic therapy. There was made a comparison of parameters of methods and results of photodynamic therapy in 2 randomized groups. Each group consisted of 45 patients. The research method was applied in the main group and the standard method was used in the comparison group. It was found that the research method allowed significant reduction of duration of irradiation compared with conventional method (at the average from 690±65sec to 470±45sec, p=0,02), though the treatment results were the same. The suggested method allowed separation of group of patients with absence of fluorescence of timorous tissue. Performance of photodynamic therapy is unreasonable for these patients.
Asunto(s)
Broncoscopía/métodos , Carcinoma de Pulmón de Células no Pequeñas , Terapia por Luz de Baja Intensidad/métodos , Neoplasias Pulmonares , Fotoquimioterapia , Carcinoma de Pulmón de Células no Pequeñas/patología , Carcinoma de Pulmón de Células no Pequeñas/terapia , Femenino , Humanos , Pulmón/diagnóstico por imagen , Neoplasias Pulmonares/patología , Neoplasias Pulmonares/terapia , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Imagen Óptica/métodos , Fotoquimioterapia/instrumentación , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/administración & dosificación , Nanomedicina Teranóstica/métodos , Resultado del TratamientoRESUMEN
Differential diagnostics of tumors of anterior mediastinum is one of the most difficult problems of thoracic surgery and oncology. The authors conducted a retrospective analysis of the results of transthoracal puncture biopsy under ultrasonic induction in 44 patients with the tumors of the anterior mediastinum. Transthoracal biopsy was carried out using the device for biopsy (Multiple Biopsy Device-MBD-23) and ultrasonic scanner (Voluson 730 Expert), the patients being under intravenous (38 patients) and under local (6 patients) anesthetization. The diagnosis was made as a result of morphological research in all 100% of patients, the biopsy being performed the second time in one patient. The general information value of puncture biopsy under ultrasonic induction was 98%. A complication (localized pneumothorax, cupping off by itself) took place only in one of the follow-up study (2%). The analysis of presented material let the authors make a conclusion that transthoracal puncture biopsy under ultrasonic induction is a safe and highly informative method of diagnostics of tumors of the anterior mediastinum in selected patients.
Asunto(s)
Biopsia Guiada por Imagen/métodos , Neoplasias del Mediastino/diagnóstico , Tórax/diagnóstico por imagen , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Broncoscopía , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Estudios Retrospectivos , Ultrasonografía , Adulto JovenRESUMEN
For 15 years now the participants of surgical operations have been using novasept for the treatment of hand and operation fields. Novasept contains synthetic cationactive substances and superficially active substances which moisten the skin and penetrate the pores. The drug possesses high bactericidal action and does not irritate the skin.
Asunto(s)
Desinfectantes , Lípidos , Compuestos de Amonio Cuaternario/uso terapéutico , Tensoactivos/uso terapéutico , Procedimientos Quirúrgicos Operativos , Evaluación Preclínica de Medicamentos , Mano/microbiología , Humanos , Pruebas de Sensibilidad Microbiana , Factores de TiempoRESUMEN
From 1975 the authors used autohemotransfusion in stomach resection for ulcer complications. The procedure was carried out upon 68 patients aged from 28 to 57. 200-350 ml of the blood were taken from these patients 4 to 7 days before operation. The routine method of donor blood conservation was used. The transfusion was performed during the operation. The patients did not develop any complications due to the blood exfusion and transfusion.