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Pak J Biol Sci ; 24(1): 99-111, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33683036

RESUMEN

BACKGROUND AND OBJECTIVE: Red onions are one of the most consumed vegetable crops in Egypt, their peel is rich in antioxidants that reduce the risk of diabetes and weight is lost. The study aimed to extract bioactive compounds present in Egyptian Red Onion Peels Waste (ROPE), increasing their efficiency and protecting them using nano-encapsulation as new emerging technology. MATERIALS AND METHODS: Extraction of the bioactive compounds in the Egyptian red onion peels was carried out to study their antioxidant activity before and after nano-emulsions and micro-capsules, their physical and morphological characteristics with their different nano-forms and their application in sponge cake products. The biological evaluation was also studied using rats and statistical analysis. RESULTS: The results showed that the ethanol extracts high content of bioactive compounds compared to water extract and that the use of nano-technique as a new emerging technology in form of nano-emulsion using sodium alginate with diameter size between 8.3-13.6 nm. Results also indicated that there was an improvement in the efficiency of antioxidant activity at high-temperature degrees during baking, with a melting point of up to 223.64°C, with an improvement in the blood sugar levels of diabetic rats and a significant decrease in body weight. CONCLUSION: Nano treatments had a protective effect on liver, safety towards kidneys, lowering blood sugar, improving the efficiency comparing to the other samples and were more acceptable to the consumer.


Asunto(s)
Fármacos Antiobesidad/administración & dosificación , Glucemia/efectos de los fármacos , Diabetes Mellitus Experimental/tratamiento farmacológico , Hipoglucemiantes/administración & dosificación , Cebollas , Extractos Vegetales/administración & dosificación , Pérdida de Peso/efectos de los fármacos , Administración Oral , Alimentación Animal , Animales , Fármacos Antiobesidad/aislamiento & purificación , Antioxidantes/administración & dosificación , Antioxidantes/aislamiento & purificación , Biomarcadores/sangre , Glucemia/metabolismo , Cápsulas , Diabetes Mellitus Experimental/sangre , Diabetes Mellitus Experimental/diagnóstico , Composición de Medicamentos , Hipoglucemiantes/aislamiento & purificación , Masculino , Cebollas/química , Extractos Vegetales/aislamiento & purificación , Raíces de Plantas , Ratas
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