RESUMEN
OBJECTIVE: To investigate the bioactivities of crude n-hexane, ethyl acetate and methanol extracts of aerial part of Boerhavia diffusa Linn. (B. diffusa) and its phytochemical analysis. METHODS: The identification of phytoconstituents and assay of antioxidant, thrombolytic, cytotoxic, antimicrobial activities were conducted using specific standard in vitro procedures. RESULTS: The results showed that the plant extracts were a rich source of phytoconstituents. Methanol extract showed higher antioxidant, thrombolytic activity and less cytotoxic activity than those of n-hexane and ethyl acetate extracts of B. diffusa. Among the bioactivities, antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of natural antioxidant. In case of antimicrobial screening, crude extracts of the plant showed remarkable antibacterial activity against tested microorganisms. All the extracts showed significant inhibitory activity against Candida albicuns, at a concentration of 1000 µg/disc. CONCLUSIONS: The present findings suggest that, the plant widely available in Bangladesh, could be a prominent source of medicinally important natural compounds.
Asunto(s)
Nyctaginaceae/química , Fitoquímicos/química , Componentes Aéreos de las Plantas/química , Extractos Vegetales/química , Extractos Vegetales/farmacología , Animales , Antiinfecciosos/química , Antiinfecciosos/farmacología , Antioxidantes/química , Artemia/efectos de los fármacos , Bacterias/efectos de los fármacos , Compuestos de Bifenilo/antagonistas & inhibidores , Dosificación Letal Mediana , Pruebas de Sensibilidad Microbiana , Óxido Nítrico/antagonistas & inhibidores , Fenoles/química , Picratos/antagonistas & inhibidores , Extractos Vegetales/toxicidadRESUMEN
A concise synthesis of APDOEGCg (3) was accomplished. Due to the reactivity of its amine group, the compound could be easily converted to the fluorescein probe 21 and immunogen probe 22 efficiently. We then demonstrated the usefulness of the probes for imaging studies and the generation of antibodies.