1.
Biochim Biophys Acta
; 1453(1): 135-40, 1999 Jan 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9989253
RESUMEN
Oral supplementation of 10 mmol/kg/day of D-ribose to a patient with an inherited deficit of adenylosuccinase, severe psychomotor retardation, and epilepsy caused a marked increase in plasma concentration and urinary excretion of urate, while minor changes in succinylpurine levels were observed. D-Ribose administration was accompanied by a slight improvement of behaviour and a progressive reduction of seizure frequency, which increased dramatically upon two attempts to withdraw the drug. Substitution of D-ribose with an equivalent amount of D-glucose did not result in an increase of seizure frequency.
Asunto(s)
Adenilosuccinato Liasa/deficiencia , Suplementos Dietéticos , Purinas/biosíntesis , Ribosa/farmacología , Adolescente , Femenino , Glucosa/metabolismo , Humanos , Examen Neurológico , Ribosa/administración & dosificación , Convulsiones/prevención & control , Transaminasas/metabolismo
2.
Ther Drug Monit
; 12(2): 210-1, 1990 Mar.
Artículo
en Inglés
| MEDLINE
| ID: mdl-2180139