RESUMEN
In experiments on mice the influence of thymic and medullary immunomodulators on the character of fatal influenza infection, the reproduction of influenza virus in pulmonary and thymic tissues and the level of MIF production was studied. Tactivin and myelolipid, used both separately and in combination, proved to be immunotherapeutic preparations capable of decreasing mortality rate by 70-95%. The immunological effects of these preparations were manifested by an increase in the functional activity of the T-link of immunity in the absence of the stimulation of antibody formation.
Asunto(s)
Activinas , Adyuvantes Inmunológicos/uso terapéutico , Médula Ósea/inmunología , Oligopéptidos , Infecciones por Orthomyxoviridae/tratamiento farmacológico , Animales , Anticuerpos Antivirales/análisis , Evaluación Preclínica de Medicamentos , Quimioterapia Combinada , Virus de la Influenza A/inmunología , Ratones , Ratones Endogámicos BALB C , Infecciones por Orthomyxoviridae/inmunología , Péptidos , Extractos del Timo , Factores de TiempoRESUMEN
The effect of a new immunomodulator taktivin (7-20 micrograms/kg subcutaneously, for 6 days) on the diuresis and tubular transport of cardiotrast (diodrast) was studied on rats. taktivin was shown to increase the tubular transport of the xenobiotic without significant changes in glomerular filtration and renal excretion of water, sodium, potassium, uric acid and creatinine. Possible mechanism of taktivin's action on the tubular transport of xenobiotics is discussed.
Asunto(s)
Adyuvantes Inmunológicos/farmacología , Diuresis/efectos de los fármacos , Yodopiraceto/farmacocinética , Túbulos Renales/efectos de los fármacos , Péptidos/farmacología , Extractos del Timo/farmacología , Animales , Transporte Biológico/efectos de los fármacos , Tasa de Filtración Glomerular/efectos de los fármacos , Túbulos Renales/fisiología , Ratas , Factores de TiempoRESUMEN
Thymus active fractions from 3-year-old sheep were shown to cause immune response stimulation to sheep red blood cells in experimental immune deficiency in mice. The fraction from fetal lamb and sheep thymus was more active than that of mature animals in increasing immune rosette-formation in the lymph of central and peripheral organs of the immune deficient mice. All the preparations recovered the number of splenocytes in immune deficient mice. Therefore, thymus active fractions obtained from sheep at different stages of ontogenesis had a stimulating effect on cell proliferation and immunogenesis.