RESUMEN
OBJECTIVE: The purpose of this study was to assess whether CAM use affected breast cancer prognosis in those who did not receive systemic therapy. DESIGN: Secondary data analysis of baseline/survey data from the Women's Healthy Eating and Living (WHEL) study. 2562 breast cancer survivors participating in the study completed baseline assessments and a CAM use questionnaire. Cox regression models were conducted to evaluate the use of CAM modalities and dietary supplements on time to an additional breast cancer event (mean follow-up=7.3 years). SETTING: A US-based multi-site randomized dietary trial. OUTCOME: Time to additional breast cancer events. RESULTS: The women who did not receive any systemic treatment had a higher risk for time to additional breast cancer events (HR=1.9, 95% CI: 1.32, 2.73) and for all-cause mortality (HR=1.7, 95% CI: 1.06, 2.73) compared to those who had received systemic treatment. Among 177 women who did not receive systemic treatment, CAM use was not significantly related to additional breast cancer events. There were no significant differences between high supplement users (≥3 formulations per day) and low supplement users in either risk for additional breast cancer events. CONCLUSION: The risk for an additional breast cancer event and/or death was higher for those who did not receive any systemic treatments; the use of dietary supplements or CAM therapies did not change this risk. This indicates that complementary and alternative therapies did not alter the outcome of breast cancer and should not be used in place of standard treatment.
Asunto(s)
Neoplasias de la Mama/terapia , Causas de Muerte , Terapias Complementarias , Suplementos Dietéticos/estadística & datos numéricos , Recurrencia Local de Neoplasia , Adulto , Anciano , Neoplasias de la Mama/mortalidad , Femenino , Encuestas Epidemiológicas , Humanos , Persona de Mediana Edad , Pronóstico , Modelos de Riesgos Proporcionales , Encuestas y Cuestionarios , Sobrevivientes , Estados UnidosRESUMEN
HYPOTHESIS: Self-reported use of complementary and alternative medicine (CAM) has been shown to increase following a cancer diagnosis, and breast cancer survivors are the heaviest users among cancer survivors. The aim of this study was to determine whether the prevalence estimate of CAM use varied according to classification of CAM. The authors used a comprehensive system to classify CAM users and test differences in demographic, lifestyle, quality of life, and cancer characteristics among them. STUDY DESIGN AND METHODS: Participants were 2562 breast cancer survivors participating in the Women's Healthy Eating and Living (WHEL) Study, aged 28 to 74 years. A structured telephone interview assessed CAM use, questioning about specific CAM practices, and whether use was related to cancer. This study examined CAM use in relation to demographics, health behaviors, and quality of life. RESULTS: Approximately 80% of the women used CAM for general purposes but only 50% reported CAM use for cancer purposes. Visual imagery, spiritual healing, and meditation were the most frequently used practices for cancer purposes. CAM use, defined as consulting a CAM practitioner and regular use, was significantly related to younger age, higher education, increased fruit and vegetable intake, and lower body mass index (P < .05). CAM users who had seen a practitioner were also more likely to report poor physical and mental health than non-CAM users (P < .05). CAM use was not associated with changes in physical and mental health between study baseline and 1-year follow-up. CONCLUSION: This study addressed important differences in the classification of CAM use among breast cancer survivors. Future studies need to further test the potential benefits and risks associated with CAM use.
Asunto(s)
Neoplasias de la Mama/terapia , Terapias Complementarias/clasificación , Terapias Complementarias/estadística & datos numéricos , Autoinforme , Terapia por Acupuntura/estadística & datos numéricos , Adulto , Factores de Edad , Anciano , Neoplasias de la Mama/diagnóstico , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/patología , Comorbilidad , Escolaridad , Femenino , Alimentos/estadística & datos numéricos , Estado de Salud , Homeopatía/estadística & datos numéricos , Humanos , Seguro de Salud/estadística & datos numéricos , Entrevistas como Asunto , Salud Mental/estadística & datos numéricos , Persona de Mediana Edad , Terapias Mente-Cuerpo/estadística & datos numéricos , Actividad Motora , Manipulaciones Musculoesqueléticas/estadística & datos numéricos , Naturopatía/estadística & datos numéricos , Calidad de Vida , Grupos Raciales/estadística & datos numéricos , Fumar/epidemiología , Sobrevivientes , Tacto Terapéutico/estadística & datos numéricos , Resultado del TratamientoRESUMEN
Previous studies examining the relationship between micronutrient intakes and survival following diagnosis of breast cancer have reported mixed results. This may be partly due to considerable variance in amounts of micronutrients consumed from diet and supplements across studies. Early-stage breast cancer survivors (N = 3081) completed four 24-h dietary and supplement recalls at the baseline assessment (1995 to 2000) and were followed for a median of 9.0 yr. Mean micronutrient intakes were compared to dietary reference intakes (DRI) to assess micronutrient adequacy for both users and nonusers of supplements. Cox regressions were performed to assess whether intakes of selected micronutrients were associated with all-cause mortality. Four hundred and twelve deaths occurred between baseline and August 2009. Among these women, more supplement users had adequate micronutrient intakes than nonusers for 15 out of 17 micronutrients. Less than 10% of supplement users (<2% of nonsupplement users) reported levels that exceeded the tolerable upper limit for each micronutrient except magnesium. After adjusting for age, tumor characteristics, and health status variables, micronutrient intakes were not significantly associated with all-cause mortality. Dietary supplements may improve overall micronutrient intakes of breast cancer survivors. However, vitamin and mineral intakes were not associated with all-cause mortality.