RESUMEN
The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and beta-sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1-4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth.
Asunto(s)
Alcaloides/farmacología , Antimaláricos/farmacología , Plasmodium falciparum/efectos de los fármacos , Quinolinas/farmacología , Rutaceae/química , Alcaloides/aislamiento & purificación , Antimaláricos/aislamiento & purificación , Dioxoles , Furanos/aislamiento & purificación , Furanos/farmacología , Estructura Molecular , Corteza de la Planta/química , Extractos Vegetales/farmacología , Plasmodium falciparum/crecimiento & desarrollo , Quinolinas/aislamiento & purificaciónRESUMEN
Eight compounds were isolated from the roots of Garcinia polyantha, and identified. Two of them, the xanthone garciniaxanthone I (1), and the triterpene, named garcinane (2), are reported as new natural products. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic studies. The structure of compound 1 was confirmed by X-ray crystallography. Among the remaining six known compounds, three were known xanthones [smeathxanthone A (3), smeathxanthone B (4), and chefouxanthone (5)], one benzophenone [isoxanthochymol (6)], one triterpene [magnificol], and one sterol [beta-sitosterol]. The in vitro antimalarial activity of isoxanthochymol (6) against Plasmodium falciparum shows strong chemosuppression of parasitic growth.
Asunto(s)
Antimaláricos/aislamiento & purificación , Garcinia/química , Plasmodium falciparum/efectos de los fármacos , Triterpenos/aislamiento & purificación , Xantonas/aislamiento & purificación , Animales , Antimaláricos/química , Antimaláricos/farmacología , Cristalografía por Rayos X , Malaria Falciparum/parasitología , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Rotación Óptica , Corteza de la Planta/química , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Plasmodium falciparum/aislamiento & purificación , Espectrometría de Masa por Ionización de Electrospray , Espectrofotometría Ultravioleta , Espectroscopía Infrarroja por Transformada de Fourier , Triterpenos/química , Triterpenos/farmacología , Xantonas/química , Xantonas/farmacologíaRESUMEN
The study of the chemical constituents of the roots of Newbouldia laevis (Bignoniaceae) has resulted in the isolation and characterization of a naphthoquinone-anthraquinone coupled pigment named newbouldiaquinone A (1) together with 14 known compounds: apigenin, chrysoeriol, newbouldiaquinone, lapachol, 2-methylanthraquinone, 2-acetylfuro-1,4-naphthoquinone, 2,3-dimethoxy-1,4-benzoquinone, oleanolic acid, canthic acid, 2-(4-hydroxyphenyl)ethyl triacontanoate, newbouldiamide, 5,7-dihydroxydehydroiso-alpha-lapachone, beta-sitosterol, and beta-sitosterol glucopyranoside. The structure elucidation of the isolated compounds was established based on spectroscopic studies, notably of the 2D NMR spectra. The antimalarial activity of compound (1) against Plasmodium falciparum in vitro shows moderate chemo suppression of parasitic growth. Its antimicrobial activity against a wide range of microorganisms was 13- and 24-fold more active against Candida gabrata and Enterobacter aerogens than the reference antibiotics nystatin and gentamycin.