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Molecules ; 26(18)2021 Sep 21.
Artículo en Inglés | MEDLINE | ID: mdl-34577171

RESUMEN

As the human life expectancy increases, age-linked diseases have become more and more frequent. The worldwide increment of dementia cases demands medical solutions, but the current available drugs do not meet all the expectations. Recently the attention of the scientific community was attracted by natural compounds, used in ancient medicine, known for their beneficial effects and high tolerability. This review is focused on Ginger (Zingiber officinale) and explore its properties against Alzheimer's Disease and Vascular Dementia, two of the most common and devastating forms of dementia. This work resumes the beneficial effects of Ginger compounds, tested in computational in vitro and in vivo models of Alzheimer's Disease and Vascular Dementia, along with some human tests. All these evidences suggest a potential role of the compounds of ginger not only in the treatment of the disease, but also in its prevention.


Asunto(s)
Demencia/tratamiento farmacológico , Extractos Vegetales/química , Sustancias Protectoras/química , Zingiber officinale/química , Catecoles/química , Catecoles/farmacología , Descubrimiento de Drogas , Alcoholes Grasos/química , Alcoholes Grasos/farmacología , Guayacol/análogos & derivados , Guayacol/química , Guayacol/farmacología , Humanos , Cetonas/química , Cetonas/farmacología , Modelos Moleculares , Extractos Vegetales/farmacología , Sustancias Protectoras/farmacología , Sesquiterpenos/química , Sesquiterpenos/farmacología , Relación Estructura-Actividad
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