RESUMEN
The influence of age of experimental animals on the antileukemic activity, toxicity and distribution of ambazone, a new potential antineoplastic agent, was studied in 2- and 12-month-old B6D2F1 mice. The predominant effect observed was a significant reduction of the antileukemic action of this compound in old-aged mice. Together with a slight increase in several toxicity parameters this caused a marked reduction of the therapeutic index in 12-month-old mice compared to younger individuals. Furthermore, a general tendency to increased ambazone levels in liver, kidneys and thymus of old-aged mice was observed. Our data therefore provide further evidence that age has to be taken into consideration as one factor that may account for the variety of drug response frequently observed during clinical therapy with anticancer agents.
Asunto(s)
Envejecimiento/efectos de los fármacos , Antineoplásicos/uso terapéutico , Leucemia P388/tratamiento farmacológico , Leucemia Experimental/tratamiento farmacológico , Mitoguazona/análogos & derivados , Envejecimiento/fisiología , Animales , Antineoplásicos/farmacocinética , Antineoplásicos/toxicidad , Radioisótopos de Carbono , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Femenino , Dosificación Letal Mediana , Leucemia P388/metabolismo , Ratones , Ratones Endogámicos , Mitoguazona/farmacocinética , Mitoguazona/uso terapéutico , Mitoguazona/toxicidad , Trasplante de Neoplasias , Distribución Tisular/fisiologíaAsunto(s)
Parto Obstétrico , Parto Domiciliario , Legislación de Enfermería , Partería , Canadá , Femenino , Humanos , Recién Nacido , EmbarazoRESUMEN
Eight of fifteen Fluorenone-Azomethines without alkylating function have been found effective against the leukemia L 1210. Little modifications concerning the structure of the compounds caused loss of effectiveness. It seems remarkably that one corresponding derivative with a nitrogen mustard group (4) was ineffective. Correlations between chemical structure and biological effect have not yet been found.