RESUMEN
The manuscript is a commenting on the article "Effects of vitamin B12, folate, and entacapone on homocysteine levels in levodopa-treated Parkinson's disease patients: A randomized controlled study", recently published by Anamnart and Kitjarak (2021), in this prestigious journal. The authors demonstrated that combination supplementation with vitamin B12 and folate was associated with significantly decreased plasma homocysteine (Hcy), suggesting that plasma Hcy levels should be monitored during levodopa treatment, and supplementation with inexpensive vitamin B12 and folate is beneficial for levodopa-treated PD patients. Considering some evidences - i) that it has to be indicated that dietary and supplemental thiamine intake has a protective effect on various medical conditions, including PD; ii) that several studies highlighted a possible relationship between PD low levels of thiamine in the serum, suggesting that elevated thiamine levels might protect against PD; iii) that thiamine deficiency is not just a common finding in patients with cardiovascular dysfunctions, but it might also have a role in the development and prognosis of PD - our research group believes that some comprehensive cardiovascular screening protocols should be developed for PD patients in order to reduce fatal events in these individuals.
Asunto(s)
Enfermedad de Parkinson , Deficiencia de Tiamina , Ácido Fólico/uso terapéutico , Homocisteína , Humanos , Levodopa/uso terapéutico , Enfermedad de Parkinson/complicaciones , Enfermedad de Parkinson/tratamiento farmacológico , Vitamina B 12Asunto(s)
Oftalmopatías/prevención & control , Própolis/uso terapéutico , Brasil , Humanos , Própolis/químicaRESUMEN
Stroke is the main cause of death and functional disability. The available therapy affects only 5% of patients, and new therapeutic approaches have been constantly tested. Transcranial photobiomodulation (PBM) is promising for its neuroprotective effect on brain injuries. Thus, the present study investigated the PBM effects in an in vivo model of ischemic stroke induced by photothrombosis (PT). Five different groups of Wistar rats were submitted or not to a daily dose of fish oil or/and laser sessions for 2 months. The ischemia volume was evaluated by stereology; GFAP, Iba and NeuN by immunohistochemistry; TNF-α, IL-1ß, IL-6, IL-10 and TGF-ß by ELISA assay. PBM influenced both the lesion volume and the GFAP. Furthermore, PBM and Ω-3 or both reduced Iba RNAm. PBM reduced TNF-α, IL-1ß, IL-6, brain damage, neuroinflammation and microglial activation, and it increased astroglial activity in peri-lesioned region after stroke.
Asunto(s)
Terapia por Luz de Baja Intensidad , Accidente Cerebrovascular , Animales , Infarto Encefálico , Humanos , Microglía , Ratas , Ratas Wistar , Accidente Cerebrovascular/complicaciones , Accidente Cerebrovascular/terapiaAsunto(s)
Ácidos Grasos Omega-3 , Cardiopatías , Síndrome Metabólico , Esquizofrenia , Muerte Súbita Cardíaca , HumanosAsunto(s)
Terapias Complementarias , Enfermedad de Parkinson , Anciano , Ciclismo , Humanos , Proyectos Piloto , CaminataRESUMEN
It is extremely difficult to estimate the occurrence of sudden unexpected death in epilepsy (SUDEP). On the other hand, discovering and carefully evaluating new risk factors that may contribute to the onset of cardiovascular abnormalities in people with refractory epilepsy may prevent fatal events in these individuals. In this context, we should not ignore that urban air pollution is a leading problem for environmental health and is able to cause serious cardiovascular dysfunctions that culminate in sudden death. In this regard, we aimed to determine whether environmental exposure to air pollution is an aggravating event for SUDEP.
Asunto(s)
Contaminación del Aire/efectos adversos , Muerte Súbita/etiología , Epilepsia/mortalidad , Anomalías Cardiovasculares/mortalidad , Exposición a Riesgos Ambientales/efectos adversos , Epilepsia/prevención & control , Ácidos Grasos Omega-3/administración & dosificación , Humanos , Factores de RiesgoRESUMEN
Since cardiovascular dysfunction may contribute to sudden unexpected death in epilepsy (SUDEP), the consumption of omega-3 fatty acids (omega-3 FAs) might be beneficial as an adjunctive therapy for SUDEP prevention. It is well recognized that omega-3 FAs exert positive effects on the cardiovascular system including heart rate (HR) reduction, a major risk factor to sudden death. Thus, we evaluated the effects of chronic supplementation of omega-3 FAs on the HR of rats with epilepsy. In agreement with our previous investigations, this study also showed that the HR of animals with epilepsy is higher than that of the control group. Quite interestingly, chronic supplementation with omega-3 FAs restored the HR of rats with epilepsy toward control values. In conclusion, although further investigations are still required, our preliminary results showed a potential preventive effect of omega-3 FA supplementation against SUDEP.