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Métodos Terapéuticos y Terapias MTCI
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1.
Brain Res Bull ; 131: 7-17, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-28274815

RESUMEN

This study explored the effect of electroacupuncture stimulation (EA) on alterations in the Hoffman reflex (H-reflex) response and gait locomotion provoked by spinal cord injury (SCI) in the rat. A compression lesion of the spinal cord was evoked by insufflating a Fogarty balloon located in the epidural space at the T8-9 spinal level of adult Wistar male rats (200-250 gr; n=60). In different groups of SCI rats, EA (frequencies: 2, 50 and 100Hz) was applied simultaneously to Huantiao (GB30), Yinmen (BL37), Jizhong (GV6) and Zhiyang (GV9) acupoints from the third post-injury day until the experimental session. At 1, 2, 3 and 4 post-injury weeks, the BBB scores of the SCI group of rats treated with EA at 50Hz showed a gradual but greater enhancement of locomotor activity than the other groups of rats. Unrestrained gait kinematic analysis of SCI rats treated with EA-50Hz stimulation showed a significant improvement in stride duration, length and speed (p<0.05), whereas a discrete recovery of gait locomotion was observed in the other groups of animals. After four post-injury weeks, the H-reflex amplitude and H-reflex/M wave amplitude ratio obtained in SCI rats had a noticeable enhancement (217%) compared to sham rats (n=10). Meanwhile, SCI rats treated with EA at 50Hz manifested a decreased facilitation of the H-reflex amplitude and H/M amplitude ratio (154%) and a reduced frequency-dependent amplitude depression of the H-reflex (66%). In addition, 50 Hz-EA treatment induced a recovery of the presynaptic depression of the Gs-VRP evoked by PBSt conditioning stimulation in the SCI rat (63.2±8.1%; n=9). In concordance with the latter, it could be suggested that 50 Hz-EA stimulation reduced the hyper-excitability of motoneurons and provokes a partial improvement of the locomotive performance and H reflex responses by a possible recovery of presynaptic mechanisms in the spinal cord of experimentally injured rats.


Asunto(s)
Electroacupuntura/métodos , Traumatismos de la Médula Espinal/terapia , Puntos de Acupuntura , Animales , Electroacupuntura/veterinaria , Marcha/fisiología , Reflejo H/fisiología , Locomoción , Masculino , Neuronas Motoras/fisiología , Ratas , Ratas Wistar , Médula Espinal/fisiopatología , Raíces Nerviosas Espinales/fisiopatología
2.
Exp Brain Res ; 232(9): 2721-9, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-24770863

RESUMEN

The aim of this study was to explore the effect of electroacupuncture (EA) applied in the Zusanli (ST36) and Sanyinjiao (SP6) points on the N1 component of the cord dorsum potential (CDP) evoked by electrical stimulation of the sural nerve (SU) in the rat. The experiments were performed in 44 Wistar rats (250-300 g) anesthetized with ketamine (100 mg/kg) and xylazine (2 mg/kg). A bilateral laminectomy was performed to expose the L3 to S2 segments of the spinal cord. The SU nerve was exposed and placed on pairs of hook electrodes for electrical stimulation. The N1-CDPs were recorded with three silver-ball electrodes located on the dorsal surface of the L5 to S1 segments. Ipsilateral high and low EA stimulation (100, 2 Hz, 6 mA, 30 min) induced a considerable reduction in the amplitude (45 ± 5.6, 41 ± 6.2%) of the N1-CDP recorded at the L6 segmental level. Recovery of the N1-CDP amplitude occurred approximately 1-3 s after EA. Sectioning of the saphenous and superficial peroneal nerves reduced the depressing effect provoked by the EA stimulation (18.7 ± 1.3, 27 ± 3.8%). Similarly, sectioning of the posterior and anterior tibial, deep peroneal and gastrocnemius nerves partially reduced the effect provoked by EA (11 ± 1.5, 9.8 ± 1.1, 12.6 ± 1.9%). Intravenous picrotoxin (1 mg/kg) also reduced the action of low and high EA (23 ± 4.8, 27 ± 5.2%). It is suggested that EA stimulation depresses non-painful sensory pathways through the activation of specific inhibitory pathways that receive modulatory actions from other sensory and muscle afferent inputs in the rat spinal cord.


Asunto(s)
Vías Aferentes/fisiología , Electroacupuntura , Potenciales Evocados/fisiología , Médula Espinal/fisiología , Puntos de Acupuntura , Vías Aferentes/efectos de los fármacos , Animales , Estimulantes del Sistema Nervioso Central/farmacología , Potenciales Evocados/efectos de los fármacos , Lateralidad Funcional/efectos de los fármacos , Laminectomía , Masculino , Picrotoxina/farmacología , Ratas , Ratas Wistar , Médula Espinal/efectos de los fármacos , Nervio Sural/efectos de los fármacos , Nervio Sural/fisiología
3.
J Acupunct Meridian Stud ; 7(1): 25-32, 2014 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24513345

RESUMEN

The longitudinal distribution of the cord dorsum potentials (CDPs) produced by electroacupuncture (EA) stimulation at acupuncture points (APs) located on the hind limbs of rats was analyzed in this study. Single electrical pulses (0.05 ms, 1 Hz) applied to the bladder (BL) and the gallbladder (GB) APs produced CDPs on several spinal segments and were composed of the following four components: an afferent volley, two negative components (N1 and N2), and one positive component (P wave). The larger evoked CDPs differed in their rostrocaudal distributions depending on the stimulated AP site, with those evoked by GB32-33 (at L3) and GB36-37 (at L4) being more caudal than those generated by BL58-59 (at L5) and BL37-38 (at L6). The CDPs produced by stimulating nonacupoints (NAPs) showed similar components and rostrocaudal distributions that were smaller in amplitude than those evoked by stimulating APs. The CDPs produced by stimulating NAPs located on a meridian acupuncture area were similar in amplitude and longitudinal distribution to those produced by stimulating APs. Our results suggest that the specificity of EA stimulation for CDPs responses is mainly related to an activation of meridian pathways associated with peripheral nerve routes rather than to a restricted point specificity of APs.


Asunto(s)
Potenciales de Acción/fisiología , Electroacupuntura/métodos , Miembro Posterior/fisiología , Médula Espinal/fisiología , Puntos de Acupuntura , Animales , Masculino , Ratas , Ratas Wistar
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