RESUMEN
OBJECTIVE: Auditory testing is not routinely performed within 4 to 6 weeks after stapedotomy because hearing acuity is thought to be transiently depressed. The early postoperative effects of the 1-shot carbon dioxide (CO2) laser have never been reported. The purpose of this study is to present data for auditory thresholds measured within 2 days of laser stapedotomy and at the last follow-up. STUDY DESIGN: The study was prospective and unblinded. SETTING: The study was conducted at the "A. Gemelli" University Hospital. METHODS: From January to December 2008, 58 subjects underwent "1-shot" CO2 laser stapedotomies for otosclerosis. Pure-tonal audiometric test was performed preoperatively 2 days after surgery and at least 1 month after surgery during the follow-up. RESULTS: The closure of air-bone gap began in the early postoperative period and continued to improve through the late postoperative period. Bone-conduction hearing thresholds were stable even in the early postoperative follow-up and remained stable trough all the course of the study. CONCLUSION: Our data, supported by the literature, suggest that 1-shot CO2 laser stapedotomy is an effective and safe procedure for the treatment of otosclerosis.
Asunto(s)
Oído Interno/lesiones , Pruebas Auditivas , Terapia por Láser , Complicaciones Posoperatorias/diagnóstico , Cirugía del Estribo , Adulto , Anciano , Anestesia Local , Audiometría , Audiometría de Tonos Puros , Umbral Auditivo/fisiología , Conducción Ósea , Femenino , Humanos , Terapia por Láser/efectos adversos , Láseres de Gas , Masculino , Persona de Mediana Edad , Otosclerosis/fisiopatología , Otosclerosis/cirugía , Valor Predictivo de las Pruebas , Estudios Prospectivos , Cirugía del Estribo/efectos adversos , Resultado del Tratamiento , Adulto JovenRESUMEN
Idebenone is a synthetic analogue of coenzyme Q10 with antioxidant properties. The present study investigated the antioxidant activity of idebenone in the rescue of acoustic trauma. Noise-induced hearing loss was induced by exposing guinea pigs to a continuous pure tone and idebenone was injected intraperitoneally 1 h before noise exposure and once daily for 3 days. Guinea pigs treated with idebenone showed significantly smaller auditory threshold shifts than unprotected control animals. Missing and apoptotic cells were identified with scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay. Protected animals presented a lesser extent of both apoptotic activation and hair cell loss in the organ of Corti. Our results suggest an antioxidant function of idebenone in protection from noise-induced hearing loss and provide a rationale for exploring therapeutic strategies in humans.