RESUMEN
CONTEXT: Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant. OBJECTIVES: To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes. MATERIALS AND METHODS: A daily dose of A. bunius extract (250 mg/kg body weight) was given orally to alloxan-induced diabetic rats for 28 days. Blood glucose, insulin, TC, TG, amylase, lipase, liver glycogen were analysed. RESULTS: Extract revealed a significant reduction in blood glucose level (80.5%) along with an increase in serum insulin (134%), lipase (90.7%) and liver glycogen level (160%). Also amylase (28.2%) activity, TC (40.2%), and TG (28.8%) levels were significantly decreased when compared with diabetic control rats. A. bunius extract improved the histo-architectural of the ß-cells. DISCUSSION AND CONCLUSION: The results suggested that A. bunius extract possess anti-diabetic activity, through the enhancement of hepatic glycogen storage and regeneration of the islet of Langerhans.