RESUMEN
The aim of the main research was investigated of interaction of neural, endocrine and immune systems under experimental postviral fatigue, behavioral reactions, level of corticosterone, changes of IL-3 and IL-10 gene expression in rats' hypothalamus and INF-α in hypothalamus and spleen were analyzed. It has been shown the decrease of physical activity, increasing of corticosterone's level and gene expression of cytokines after injection of Poly I:C as a model of postviral fatigue. After remedication of Poly I:C increasing of physical activity was shown.
Asunto(s)
Síndrome de Fatiga Crónica/fisiopatología , Hipotálamo/fisiopatología , Actividad Motora/inmunología , Bazo/fisiopatología , Animales , Corticosterona/sangre , Modelos Animales de Enfermedad , Síndrome de Fatiga Crónica/inducido químicamente , Síndrome de Fatiga Crónica/genética , Síndrome de Fatiga Crónica/inmunología , Expresión Génica , Hipotálamo/inmunología , Inmunidad Innata , Interferón-alfa/genética , Interferón-alfa/inmunología , Interleucina-10/genética , Interleucina-10/inmunología , Interleucina-3/genética , Interleucina-3/inmunología , Masculino , Actividad Motora/genética , Poli I-C , Ratas , Ratas Wistar , Bazo/inmunología , NataciónRESUMEN
In experiments on rats we studied the effect of cyclophosphamide-containing drug Cytoxan on activation of neurons in hypothalamic structures involved in the regulation of natural killer cell activity in the spleen and changes in cytotoxicity of these cells. Administration of Cytoxan in a dose of 60 mg/kg increased the number of c-Fos-positive cells in the ventromedial hypothalamus and lateral hypothalamic area and reduced interferon-alpha-induced cytotoxic activity of natural killer cells. Our findings attest to the involvement of central mechanisms of regulation of splenic natural killer cells into side effects of Cytoxan.