1.
Bioorg Med Chem
; 19(23): 7033-43, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22044656
RESUMEN
A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.