RESUMEN
The influence of Sorbus sibirica, Calendula officinalis and Althaea officinalis extracts on the humoral immune response and nonspecific resistance of mice to immunosuppression by cyclophosphan was studied. It was shown that these extracts are not inferior to Echinacea purpurea tincture in terms of stimulation of humoral immune response, phagocytic and bactericidal activity of peritoneal macrophages but exceed effect of E. purpurea on phagocytic activity of peripheral blood neutrophils.
Asunto(s)
Inmunidad Innata , Síndromes de Inmunodeficiencia/tratamiento farmacológico , Terapia de Inmunosupresión/métodos , Inmunosupresores/uso terapéutico , Macrófagos Peritoneales/inmunología , Fitoterapia/métodos , Preparaciones de Plantas/uso terapéutico , Animales , Ciclofosfamida/uso terapéutico , Modelos Animales de Enfermedad , Echinacea , Síndromes de Inmunodeficiencia/inmunología , Síndromes de Inmunodeficiencia/patología , Macrófagos Peritoneales/efectos de los fármacos , Macrófagos Peritoneales/patología , Masculino , Ratones , Ratones Endogámicos CBA , Neutrófilos/efectos de los fármacos , Neutrófilos/inmunología , Neutrófilos/patología , Resultado del TratamientoRESUMEN
Extract of Filipendula ulmaria (L.) Maxim administered intragastrically in doses 10, 50, 150 and 500 mg/kg stimulated both inductive and productive phases of the humoral immunity response in CBA/CaLac and C57BL/6 mice. The extract also exhibited pronounced antiinflammatory effect, which was manifested by a decrease in the synthesis of interleukin-2 by splenocytes and by suppression of proinflammatory cytokines production in delayed-type hypersensitivity reaction. At the same time, Filipendula ulmaria extract did not influence the functional activity of peritoneal macrophages.
Asunto(s)
Antiinflamatorios/farmacología , Formación de Anticuerpos/efectos de los fármacos , Filipendula , Hipersensibilidad Tardía/inmunología , Interleucina-2/inmunología , Extractos Vegetales/farmacología , Animales , Antiinflamatorios/química , Formación de Anticuerpos/inmunología , Relación Dosis-Respuesta a Droga , Filipendula/química , Hipersensibilidad Tardía/tratamiento farmacológico , Macrófagos Peritoneales/inmunología , Masculino , Ratones , Extractos Vegetales/química , Bazo/inmunologíaRESUMEN
The safety of bayacon, a new drug based on Baikal aconite intended for the treatment of inflammation-proliferative dermatitis (psoriasis), was studied on a preclinical level. With respect to a single introduction in rats and mice, the drug is classified as a low-toxicity substance. However, a 3-month oral administration of bayacon (0.25, 0.5, and 2.5 mg/kg) in rats showed a number of dose-dependent functional and morphological changes. A dose of 2.5 mg/kg induced weak hyporegenerative anemia, neutrophile leukocytosis, and dystrophic changes in the stomach mucosa, heart, liver, and kidneys. All these symptoms disappeared within two weeks after abolition of the drug. Oral administration of bayacon (0.1 and 0.5 mg/kg) in rabbits produced no pathological morphofunctional changes in the organs and tissues studied. In rats, bayacon 2.5, 0.5, and 0.25 mg/kg doses of bayacon led to dose-dependent changes in some characteristics of the reproduction system. The drug did not influence the expression of allergic reactions and showed no immunotoxicity and mutagenicity manifestations.