RESUMEN
To understand the contamination characteristics and ecological risk of antibiotics in contaminated fields of pharmaceutical plantsï¼ samples of the surface soilï¼ soil columnï¼ wastewater treatment process waterï¼ ground waterï¼ and residue dregs were collected from two typical antibiotic pharmaceutical plants in South and North China. A total of 87 commonly used antibiotics were quantified using ultrasound extraction-solid phase extraction and ultra-high performance liquid chromatography-mass spectrometry. The results showed that a total of 31 antibiotics of five classes were detected in all types of samplesï¼ and the maximum concentrations at each sampling point in the surface soilï¼ soil columnï¼ residue dregsï¼ wastewater treatment process waterï¼ and groundwater were 420 ng·g-1ï¼ 595 ng·g-1ï¼ 139 ng·g-1ï¼ 1 151 ng·L-1ï¼ and 6.65 ng·L-1ï¼ respectively. Most of the antibiotics were found in the surface soilï¼ showing a decreasing trend with the depth of the soil column. The ecological risk assessment indicated that sulfamethazineï¼ sulfaquinoxalineï¼ tetracyclineï¼ chlorotetracyclineï¼ and D-sorbitol were at higher risk. Improving the efficiency of antibiotic removal from pharmaceutical wastewater and preventing production shop leaks are effective measures of controlling antibiotic contamination into and around fields in pharmaceutical plants.