RESUMEN
The study examined the effects of a novel neurotropic medication based on a lithium complex composed of lithium citrate, polymethylsiloxane, and aluminum oxide on electrophysiological parameters of the rat brain. In contrast to lithium carbonate (the reference drug), the novel preparation resulted in a wave-like dynamics of electrical activity in the visual cortex. Rhythmic photic stimulation of the rats treated with lithium carbonate resulted in appearance of the signs attesting to up-regulation of excitability of cerebral cortex in all examined ranges. In contrast, the complex lithium preparation diminished the delta power spectrum, which was the only affected frequency band. It is hypothesized that the complex lithium medication induces milder activation of the cerebral cortex in comparison with lithium carbonate. The novel medication composed of lithium citrate, aluminum oxide, and polymethylsiloxane, is characterized by greater efficacy and safety than the preparation based on inorganic lithium salt (lithium carbonate).
Asunto(s)
Corteza Cerebral/efectos de los fármacos , Corteza Cerebral/metabolismo , Litio/farmacología , Óxido de Aluminio/farmacología , Animales , Encéfalo/efectos de los fármacos , Encéfalo/metabolismo , Citratos/farmacología , Fenómenos Electrofisiológicos/efectos de los fármacos , Litio/química , Carbonato de Litio/farmacología , Masculino , Ratas , Siliconas/farmacologíaRESUMEN
Antibodies to cyclophosphamide obtained by homeopathic potentiation and administered in ultralow doses exhibit no antiblastic activity and did not modulate the effectiveness of cyclophosphamide during antitumor therapy of animals with transplanted tumors (Lewis lung carcinoma and Ehrlich adenocarcinoma).
Asunto(s)
Anticuerpos/uso terapéutico , Antineoplásicos Alquilantes/uso terapéutico , Carcinoma de Ehrlich/tratamiento farmacológico , Carcinoma Pulmonar de Lewis/tratamiento farmacológico , Ciclofosfamida/inmunología , Ciclofosfamida/uso terapéutico , Citostáticos/uso terapéutico , Animales , Anticuerpos/inmunología , Relación Dosis-Respuesta a Droga , Ratones , Ratones Endogámicos C57BL , Neoplasias Experimentales/tratamiento farmacológicoRESUMEN
Experiments on animals with transplanted tumors (Lewis lung carcinoma and carcinosarcoma Walker-256) showed that combination treatment with cyclophosphane and its homeopathically potentiated forms increases antiblastic activity of the preparation.
Asunto(s)
Antineoplásicos Alquilantes/farmacología , Ciclofosfamida/farmacología , Homeopatía/métodos , Animales , Carcinoma 256 de Walker/patología , Carcinoma Pulmonar de Lewis/patología , Citostáticos/farmacología , Femenino , Ratones , Ratones Endogámicos C57BL , Trasplante de Neoplasias , RatasRESUMEN
Bioactive additive mammoleptin used for the treatment of fibrocystic breast disease did not stimulate the growth of primary tumors and metastases in mice with transplanted tumors. Mammoleptin in high doses inhibited the growth of Ehrlich adenocarcinoma and metastatic spreading of solid tumors.