RESUMEN
Phellodendron bark ("Obaku") is an important crude drug used in Kampo-medicine. Recently, powder formulation of phellodendron bark was approved as an "efficacious treatment for bruise, sprain, and periodontal diseases", and it has been marketed as an OTC agent. To obtain this approval, the examination of quality control-related characteristics is necessary. Therefore, we established a quantitative method for jatrorrhizine, palmatine, and berberine determination. In this study, we compared the contents of the three constituents obtained from the extracts of Japanese and Chinese phellodendron bark and found remarkable difference.
Asunto(s)
Alcaloides/análisis , Berberina/análisis , Phellodendron/química , Corteza de la Planta/química , Alcaloides/aislamiento & purificación , Berberina/análogos & derivados , Berberina/aislamiento & purificación , Alcaloides de Berberina/análisis , Alcaloides de Berberina/aislamiento & purificación , China , Cromatografía Líquida de Alta Presión/métodos , Estabilidad de Medicamentos , Japón , Difracción de Polvo , Control de CalidadRESUMEN
ãSaposhnikoviae Radix ("Boufu") is an important crude drug used in Kampo formulation. It is extracted from wild-type plants. However, recently, extraction has become difficult because of a decrease in wild-type plants. Therefore, cultivated plants account for the majority of the market, from which the crude drug is extracted. However, the cultivation techniques used are not sufficient to obtain the desirable extracts. In this study, we compared the contents of the extract and the quantitative values of characteristic constituents obtained from wild-type and cultivated plants, and found a remarkable difference. Therefore, it is considered that these indicators play an important role in the establishment of better cultivation technology.